Fig. 2
Neuropathologic evaluation of regional digital pathology measures of tau and amyloid-β pathology in comparison to plasma p-tau181 and p-tau217 in parietal cortex. Utilizing the same epitope to immunohistochemically evaluate regional tau pathology in inferior parietal cortex, tau burden measures were compared to p-tau plasma levels (A, C). pT181 tau burden measures strongly associated with p-tau181 plasma levels (A), with the association even stronger between pT217 and p-tau217 plasma levels (C). Digital pathology measures of amyloid-β (6F/3D) were additionally compared to plasma p-tau levels (B, D). Amyloid-β burden strongly associated with ptau-181 (B). The strongest overall association of digital pathology measures was observed between amyloid-β (6F/3D) and p-tau217 (D). P-tau181 (A-B) and p-tau217 (C-D) were examined across all individuals studied with AD shown as triangles, PA as diamonds, and primary tauopathies as circles. Spearman correlation and corresponding significance displayed. Case with high creatinine was not included. Trendline with 95% confidence interval was computed from a linear model. Data presented are Spearman correlation and corresponding significance. Acronyms: AD Alzheimer’s disease, AGD argyrophilic grain disease, MSD meso scale discovery, PA pathological aging, PART primary age-related tauopathy, PSP progressive supranuclear palsy, p-tau phosphorylated tau for plasma levels, pT phosphorylated threonine for immunohistochemical measures of tau