Fig. 2
From: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
Trem2 H157Y enhances synaptic plasticity. A. The input–output curves for WT and Hom mice at 6 months of age are shown as linear regressions of fEPSP slopes corresponding to pre-synaptic fiber volley amplitudes. WT, n/N = 21 brain slices from 9 mice; Hom, n/N = 18/8; mixed sex. B. Paired-pulse facilitation profiles are shown. Ratios of fEPSP slopes evoked by second pulse and first pulse were calculated and plotted versus the corresponding inter-pulse intervals. WT, n/N = 17/8; Hom, n/N = 14/7; mixed sex. C. Theta-Burst Stimulus (TBS) induced LTP profiles for WT and Hom mice are shown as averaged and normalized fEPSP slopes. Example baseline (black arrow, black trace) and last-minute (blue arrow, black trace) fEPSP traces are shown in the inset frame. D. The average fEPSP slopes in the last five minutes were compared between WT and Hom mice. WT, n/N = 20/9; Hom, n/N = 16/9; mixed sex. Data are presented as Mean ± SEM. One-Way ANOCOVA with comparison of slopes was used in A. Wilcoxon Rank-sum tests were used in B and D. N.S., not significant. *p < 0.05. **p < 0.01