From: Altered plasma protein profiles in genetic FTD – a GENFI study
Non-carriers (NC) | Presymptomatic mutation carriers (PMC) | Symptomatic mutation carriers (SMC) | Total | p-value | |
---|---|---|---|---|---|
No. of participants | 276 | 280 | 137 | 693 | |
Age, mean years (SD) | 47 (14) | 45 (12) | 63 (9) | 49 (14) | < 0.001a |
Females (%) | 152 (55) | 174 (62) | 57 (42) | 383 (55) | < 0.001b |
Mutated gene (%) | 417 (60) | ||||
GRN | 133 (48) | 49 (36) | |||
C9orf72 | 96 (34) | 62 (45) | |||
MAPT | 51 (18) | 26 (19) | |||
Age at onset, mean years (SD) | |||||
GRN | 61 (8) | ||||
C9orf72 | 60 (9) | ||||
MAPT | 51 (8) |