Fig. 4
From: Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease
ADAD mutation differences in MRI measures over the course of disease progression. Scatterplots of cortical signature thickness (A), precuneus thickness (B), and hippocampus volume (C), as a function of EYO. Curves and shaded regions reflect regression fits derived from generalized additive mixed models (GAMMs) and simulation-based simultaneous 83.4% confidence intervals for comparison of two groups. Vertical dashed lines reflect EYO of 0. Vertical solid lines reflect the earliest EYOs at which MCs significantly differed from NCs. Axis labels and outlier points have been censored to prevent unblinding of participant mutation-carrier status. D. Violin plot of the earliest EYOs at which MCs significantly differed from NCs in the four MRI measures in 10,000 bootstrapped simulations