Fig. 1From: Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson’s diseaseVolcano Plot of the MWAS results from metabolomics LCMS data derived from both the (A) C18 negative and (B) HILIC positive results. Horizontal lines are shown at FDR≤0.05 and vertical lines are shown at log2FC ±0.5 and dashed lines at log2FC ±0.25. Metabolite features with a -log10(FDR)>15 and/or log2FC>2 are designated by the triangle shape and shown at the -log10(FDR)=15 and or log2FC =2 lines. Exact results can be found in Supplemental Tables 2 (C18 metabolites) and 3 (HILIC metabolites). C Violin plots show the top three metabolites from the MWAS by FDR that could be annotated at the highest confidence, excluding PD medication-associated metabolites, and separated by the independent study populations.Back to article page