Molecular Neurodegeneration

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Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease

Authors: Suhyun Kim, Heejung Chun, Yunha Kim, Yeyun Kim, Uiyeol Park, Jiyeon Chu, Mridula Bhalla, Seung-Hye Choi, Ali Yousefian-Jazi, Sojung Kim, Seung Jae Hyeon, Seungchan Kim, Yeonseo Kim, Yeon Ha Ju, Seung Eun Lee, Hyunbeom Lee…

Content type: Research article 23 July 2024
Tau protein profiling in tauopathies: a human brain study

Authors: Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M. Burmann, Michael Perkinton, Nicholas J. Ashton, Nick C. Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow…

Content type: Research article 19 July 2024
The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells

Authors: Omri Zveik, Ariel Rechtman, Tal Ganz and Adi Vaknin-Dembinsky

Content type: Review 12 July 2024
Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury

Authors: Celeste Parra Bravo, Karen Krukowski, Sarah Barker, Chao Wang, Yaqiao Li, Li Fan, Edwin Vázquez-Rosa, Min-Kyoo Shin, Man Ying Wong, Louise D. McCullough, Ryan S. Kitagawa, H. Alex Choi, Angela Cacace, Subhash C. Sinha, Andrew A. Pieper, Susanna Rosi…

Content type: Research article 24 June 2024
Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits

Authors: Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K. Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass and Bettina Schmid

Content type: Research article 20 June 2024

FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms

TREM2 dependent and independent functions of microglia in Alzheimer’s disease

APOE effects on regional tau in preclinical Alzheimer’s disease

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer’s disease: review, recommendation, implementation and application

Tauopathies: new perspectives and challenges

Advances in sequencing technologies for amyotrophic lateral sclerosis research

ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies

Solving neurodegeneration: common mechanisms and strategies for new treatments

Aims and scope

Molecular Neurodegeneration (MN) is an open access, peer-reviewed journal dedicated to publishing groundbreaking research in the field of neurodegeneration. Our mission is to foster a deeper understanding of neurodegenerative diseases, including but not limited to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, glaucoma, and macular degeneration, to inform novel diagnosis and effective therapy. We aim to publish innovative studies addressing the complex mechanisms of neurodegenerative disorders at the molecular, cellular, and systems levels, with a strong emphasis on broad impact and scientific rigor.

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Glial and Vascular Contributions to Neurodegenerative Diseases

See Molecular Neurodegeneration's ongoing Collection on Glial and Vascular Contributions to Neurodegenerative Diseases.

ALS: Challenges and New Advances

New Content Item

See Molecular Neurodegeneration's ongoing Collection on ALS: Challenges and New Advances.

Ongoing and Past Collections

Glial and Vascular Contributions to Neurodegenerative Diseases
ALS: Challenges and New Advances
Alzheimer's Disease: Challenges for the next decade
Parkinson's Disease - A Series of Reviews
Novel Systems and Emerging Concepts
Basic biology and disease pathways

News from Alzforum

Transcriptomics Paint Astrocytes as Source of Cognitive Resilience

26 July 2024
Tau PET Misses Early AD Pathology, Primary Age-Related Tauopathy

26 July 2024
Perineuronal Pockets Prevent Spillage from Synapses

23 July 2024

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Molecular Neurodegeneration

Articles

Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease

Tau protein profiling in tauopathies: a human brain study

The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells

Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury

Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits

Aims and scope

Collections

Glial and Vascular Contributions to Neurodegenerative Diseases

ALS: Challenges and New Advances

Ongoing and Past Collections

Glial and Vascular Contributions to Neurodegenerative Diseases
ALS: Challenges and New Advances
Alzheimer's Disease: Challenges for the next decade
Parkinson's Disease - A Series of Reviews
Novel Systems and Emerging Concepts
Basic biology and disease pathways

News from Alzforum

Transcriptomics Paint Astrocytes as Source of Cognitive Resilience

Tau PET Misses Early AD Pathology, Primary Age-Related Tauopathy

Perineuronal Pockets Prevent Spillage from Synapses

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