Molecular Neurodegeneration

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Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury

Authors: Celeste Parra Bravo, Karen Krukowski, Sarah Barker, Chao Wang, Yaqiao Li, Li Fan, Edwin Vázquez-Rosa, Min-Kyoo Shin, Man Ying Wong, Louise D. McCullough, Ryan S. Kitagawa, H. Alex Choi, Angela Cacace, Subhash C. Sinha, Andrew A. Pieper, Susanna Rosi…

Content type: Research article 24 June 2024
Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits

Authors: Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K. Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass and Bettina Schmid

Content type: Research article 20 June 2024
Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration

Authors: Juan Ignacio Jiménez-Loygorri, Álvaro Viedma-Poyatos, Raquel Gómez-Sintes and Patricia Boya

Content type: Research article 18 June 2024
Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging

Authors: Ethan R. Roy, Sanming Li, Sepideh Saroukhani, Yanyu Wang and Wei Cao

Content type: Research article 18 June 2024
Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS

Authors: Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa McAlonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don W. Cleveland, James Shorter and Sandrine Da Cruz

Content type: Research article 11 June 2024

FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms

TREM2 dependent and independent functions of microglia in Alzheimer’s disease

APOE effects on regional tau in preclinical Alzheimer’s disease

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer’s disease: review, recommendation, implementation and application

Tauopathies: new perspectives and challenges

Advances in sequencing technologies for amyotrophic lateral sclerosis research

ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies

Solving neurodegeneration: common mechanisms and strategies for new treatments

Aims and scope

Molecular Neurodegeneration (MN) is an open access, peer-reviewed journal dedicated to publishing groundbreaking research in the field of neurodegeneration. Our mission is to foster a deeper understanding of neurodegenerative diseases, including but not limited to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, glaucoma, and macular degeneration, to inform novel diagnosis and effective therapy. We aim to publish innovative studies addressing the complex mechanisms of neurodegenerative disorders at the molecular, cellular, and systems levels, with a strong emphasis on broad impact and scientific rigor.

Collections

Glial and Vascular Contributions to Neurodegenerative Diseases

See Molecular Neurodegeneration's ongoing Collection on Glial and Vascular Contributions to Neurodegenerative Diseases.

ALS: Challenges and New Advances

New Content Item

See Molecular Neurodegeneration's ongoing Collection on ALS: Challenges and New Advances.

Ongoing and Past Collections

Glial and Vascular Contributions to Neurodegenerative Diseases
ALS: Challenges and New Advances
Alzheimer's Disease: Challenges for the next decade
Parkinson's Disease - A Series of Reviews
Novel Systems and Emerging Concepts
Basic biology and disease pathways

News from Alzforum

Remember Amyloid-eta? A Decade Later, News on a Physiological Function

30 June 2024
T Cells in the Brain Goad Microglia to Muddle Myelin

29 June 2024
Microglial Transplants Reverse Age-Related Pathology in Mice

28 June 2024

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Molecular Neurodegeneration

Articles

Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury

Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits

Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration

Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging

Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS

Aims and scope

Collections

Glial and Vascular Contributions to Neurodegenerative Diseases

ALS: Challenges and New Advances

Ongoing and Past Collections

Glial and Vascular Contributions to Neurodegenerative Diseases
ALS: Challenges and New Advances
Alzheimer's Disease: Challenges for the next decade
Parkinson's Disease - A Series of Reviews
Novel Systems and Emerging Concepts
Basic biology and disease pathways

News from Alzforum

Remember Amyloid-eta? A Decade Later, News on a Physiological Function

T Cells in the Brain Goad Microglia to Muddle Myelin

Microglial Transplants Reverse Age-Related Pathology in Mice

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