Molecular Neurodegeneration

Featured video: The role of non-coding RNAs in Alzheimer’s disease

Video abstract summarizing new research published in Molecular Neurodegeneration. "Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease", De Jager et al. 2017

Content type: Research article
| 6 September 2018

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

Authors: Xianyuan Xiang, Thomas M. Piers, Benedikt Wefers, Kaichuan Zhu, Anna Mallach, Bettina Brunner, Gernot Kleinberger, Wilbur Song, Marco Colonna, Jochen Herms, Wolfgang Wurst, Jennifer M. Pocock and Christian Haass
Content type: Research article
| 4 September 2018

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Authors: Julia K. Götzl, Alessio-Vittorio Colombo, Katrin Fellerer, Anika Reifschneider, Georg Werner, Sabina Tahirovic, Christian Haass and Anja Capell
Content type: Research article
| 29 August 2018

Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase

Authors: Bruno Becker, Faisal Hayat Nazir, Gunnar Brinkmalm, Elena Camporesi, Hlin Kvartsberg, Erik Portelius, Martina Boström, Marie Kalm, Kina Höglund, Maria Olsson, Henrik Zetterberg and Kaj Blennow
Content type: Methodology
| 21 August 2018

Long-read sequencing across the C9orf72 ‘GGGGCC’ repeat expansion: implications for clinical use and genetic discovery efforts in human disease

Authors: Mark T. W. Ebbert, Stefan L. Farrugia, Jonathon P. Sens, Karen Jansen-West, Tania F. Gendron, Mercedes Prudencio, Ian J. McLaughlin, Brett Bowman, Matthew Seetin, Mariely DeJesus-Hernandez, Jazmyne Jackson, Patricia H. Brown, Dennis W. Dickson, Marka van Blitterswijk, Rosa Rademakers, Leonard Petrucelli…
Content type: Research article
| 20 August 2018

PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

Authors: Justin Rustenhoven, Amy M. Smith, Leon C. Smyth, Deidre Jansson, Emma L. Scotter, Molly E. V. Swanson, Miranda Aalderink, Natacha Coppieters, Pritika Narayan, Renee Handley, Chris Overall, Thomas I. H. Park, Patrick Schweder, Peter Heppner, Maurice A. Curtis, Richard L. M. Faull…

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Content type: Research article
| 24 August 2012

Exosomal cell-to-cell transmission of alpha synuclein oligomers

Authors: Karin M Danzer, Lisa R Kranich, Wolfgang P Ruf, Ozge Cagsal-Getkin, Ashley R Winslow, Liya Zhu, Charles R Vanderburg and Pamela J McLean
Content type: Research article
| 12 April 2007

Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1polymorphisms

Authors: Suzanne E Wahrle, Aarti R Shah, Anne M Fagan, Scott Smemo, John SK Kauwe, Andrew Grupe, Anthony Hinrichs, Kevin Mayo, Hong Jiang, Leon J Thal, Alison M Goate and David M Holtzman
Content type: Review
| 22 November 2013

Drosophila melanogaster as a model organism for Alzheimer’s disease

Authors: Katja Prüßing, Aaron Voigt and Jörg B Schulz
Content type: Review
| 21 June 2013

Fluid biomarkers in Alzheimer’s disease – current concepts

Authors: Christoffer Rosén, Oskar Hansson, Kaj Blennow and Henrik Zetterberg
Content type: Review
| 15 November 2007

The Alzheimer's disease β-secretase enzyme, BACE1

Authors: Sarah L Cole and Robert Vassar

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Editors-in-Chief

Guojun Bu, Mayo Clinic, USA
Huaxi Xu, Sanford Burnham Prebys Medical Discovery Institute, USA

Aims and scope

Molecular Neurodegeneration is an open access, peer-reviewed journal that encompasses all aspects of neurodegeneration research at the molecular and cellular levels.

Society partner

Molecular Neurodegeneration is the official journal of the BrightFocus Foundation.

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Upcoming conference

The 5^th international conference on Molecular Neurodegeneration
ICMN 2018: Overlapping Pathologies and Common Mechanisms

June 11 – 13, 2018

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News from Alzforum

Flortaucipir Imaging Distinguishes Alzheimer’s From Other Disorders

22 September 2018
In Conditional BACE1 Knockouts, Hippocampal Axons Compromised

21 September 2018
Does LRRK2 Sweep α-Synuclein from the Cell?

18 September 2018

Latest collections

2016

Thematic series
Molecular Neurodegeneration
Novel Systems and Emerging Concepts
Molecular Neurodegeneration
Collection published: 7 December 2016

2014

Thematic series
Molecular Neurodegeneration
Basic biology and disease pathways
Molecular Neurodegeneration
Collection published: 12 September 2014

Molecular Neurodegeneration

Featured video: The role of non-coding RNAs in Alzheimer’s disease

Articles

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase

Long-read sequencing across the C9orf72 ‘GGGGCC’ repeat expansion: implications for clinical use and genetic discovery efforts in human disease

PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

Exosomal cell-to-cell transmission of alpha synuclein oligomers

Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1polymorphisms

Drosophila melanogaster as a model organism for Alzheimer’s disease

Fluid biomarkers in Alzheimer’s disease – current concepts

The Alzheimer's disease β-secretase enzyme, BACE1

Latest Tweets

Editors-in-Chief

Aims and scope

Society partner

Upcoming conference

News from Alzforum

Flortaucipir Imaging Distinguishes Alzheimer’s From Other Disorders

In Conditional BACE1 Knockouts, Hippocampal Axons Compromised

Does LRRK2 Sweep α-Synuclein from the Cell?

Latest collections

2016

2014

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2017 Journal Metrics

Molecular Neurodegeneration

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