Molecular Neurodegeneration

Articles

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MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease

Authors: Lu Geng, Wenqing Gao, Hexige Saiyin, Yuanyuan Li, Yu Zeng, Zhifei Zhang, Xue Li, Zuolong Liu, Qiang Gao, Ping An, Ning Jiang, Xiaofei Yu, Xiangjun Chen, Suhua Li, Lei Chen, Boxun Lu…

Content type: Research article 1 December 2023
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model

Authors: Qiuchen Zhao, Megi Maci, Morgan R. Miller, Heng Zhou, Fang Zhang, Moustafa Algamal, Yee Fun Lee, Steven S. Hou, Stephen J. Perle, Hoang Le, Alyssa N. Russ, Eng H. Lo, Dmitry Gerashchenko, Stephen N. Gomperts, Brian J. Bacskai and Ksenia V. Kastanenka

Content type: Research article 1 December 2023
Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

Authors: Gizem Terzioglu and Tracy L. Young-Pearse

Content type: Review 29 November 2023
Characterization of APOE Christchurch carriers in 455,306 UK Biobank participants

Authors: Karen Y. He, Ekaterina A. Khramtsova, Alfredo Cabrera-Socorro, Yanfei Zhang, Shuwei Li, Brice A. J. Sarver, Bart Smets, Qingqin S. Li, Louis De Muynck, Antonio R. Parrado, Simon Lovestone and Mary Helen Black

Content type: Letter to the Editor 28 November 2023
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains

Authors: Morgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El-Agnaf and Abid Oueslati

Content type: Research article 27 November 2023

FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms

TREM2 dependent and independent functions of microglia in Alzheimer’s disease

APOE effects on regional tau in preclinical Alzheimer’s disease

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer’s disease: review, recommendation, implementation and application

Tauopathies: new perspectives and challenges

Advances in sequencing technologies for amyotrophic lateral sclerosis research

ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies

Solving neurodegeneration: common mechanisms and strategies for new treatments

Aims and scope

Molecular Neurodegeneration is an open access, peer-reviewed journal that encompasses all aspects of neurodegeneration research at the molecular and cellular levels.

Collections

Glial and Vascular Contributions to Neurodegenerative Diseases

See Molecular Neurodegeneration's ongoing Collection on Glial and Vascular Contributions to Neurodegenerative Diseases.

ALS: Challenges and New Advances

New Content Item

See Molecular Neurodegeneration's ongoing Collection on ALS: Challenges and New Advances.

Ongoing and Past Collections

Glial and Vascular Contributions to Neurodegenerative Diseases
ALS: Challenges and New Advances
Alzheimer's Disease: Challenges for the next decade
Parkinson's Disease - A Series of Reviews
Novel Systems and Emerging Concepts
Basic biology and disease pathways

News from Alzforum

And Then There Were Five: CSF Proteomics Defines Alzheimer’s Subtypes

07 December 2023
Two New p-Tau217 Blood Tests Join a Crowded Field

01 December 2023
Plasma p-Tau-217 Assays Work Well, But No Home Run for Diagnosis

30 November 2023

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Molecular Neurodegeneration

Articles

MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease

Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model

Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

Characterization of APOE Christchurch carriers in 455,306 UK Biobank participants

Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains

Aims and scope

Collections

Glial and Vascular Contributions to Neurodegenerative Diseases

ALS: Challenges and New Advances

Ongoing and Past Collections

Glial and Vascular Contributions to Neurodegenerative Diseases
ALS: Challenges and New Advances
Alzheimer's Disease: Challenges for the next decade
Parkinson's Disease - A Series of Reviews
Novel Systems and Emerging Concepts
Basic biology and disease pathways

News from Alzforum

And Then There Were Five: CSF Proteomics Defines Alzheimer’s Subtypes

Two New p-Tau217 Blood Tests Join a Crowded Field

Plasma p-Tau-217 Assays Work Well, But No Home Run for Diagnosis

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