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  1. Content type: Research article

    Retinitis pigmentosa (RP) is a group of hereditary retinal neurodegenerative conditions characterized by primary dysfunction and death of photoreceptor cells, resulting in visual loss and, eventually, blindnes...

    Authors: Alonso Sánchez-Cruz, Beatriz Villarejo-Zori, Miguel Marchena, Josefa Zaldivar-Díez, Valle Palomo, Carmen Gil, Ignacio Lizasoain, Pedro de la Villa, Ana Martínez, Enrique J. de la Rosa and Catalina Hernández-Sánchez

    Citation: Molecular Neurodegeneration 2018 13:19

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  2. Content type: Research article

    Proteolytic processing of the prion protein (PrPC) by endogenous proteases generates bioactive membrane-bound and soluble fragments which may help to explain the pleiotropic roles of this protein in the nervous s...

    Authors: Luise Linsenmeier, Behnam Mohammadi, Sebastian Wetzel, Berta Puig, Walker S. Jackson, Alexander Hartmann, Keiji Uchiyama, Suehiro Sakaguchi, Kristina Endres, Jörg Tatzelt, Paul Saftig, Markus Glatzel and Hermann C. Altmeppen

    Citation: Molecular Neurodegeneration 2018 13:18

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  3. Content type: Research article

    Aging is the strongest risk factor for neurodegenerative diseases and extended age results in neuronal degeneration and functional decline in the visual system. Among many contributing factors to age-related d...

    Authors: Todd McLaughlin, Marek Falkowski, Jae Whan Park, Stephen Keegan, Michael Elliott, Joshua J. Wang and Sarah X. Zhang

    Citation: Molecular Neurodegeneration 2018 13:16

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  4. Content type: Research article

    Traumatic Brain Injury (TBI) is a major cause of disability and mortality, to which there is currently no comprehensive treatment. Blood Brain Barrier (BBB) dysfunction is well documented in human TBI patients...

    Authors: Bevan S. Main, Sonia Villapol, Stephanie S. Sloley, David J. Barton, Maia Parsadanian, Chinyere Agbaegbu, Kathryn Stefos, Mondona S. McCann, Patricia M. Washington, Olga C. Rodriguez and Mark P. Burns

    Citation: Molecular Neurodegeneration 2018 13:17

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  5. Content type: Research article

    TREM2 is an innate immune receptor specifically expressed in microglia. Coding variations in TREM2 have been reported to increase the risk for Alzheimer’s disease (AD) and other neurodegenerative diseases. Whi...

    Authors: Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A. Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang, Dan Can, Huaxi Xu, Guojun Bu and Xiao-Fen Chen

    Citation: Molecular Neurodegeneration 2018 13:15

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  6. Content type: Research article

    Metabolically-obese, normal-weight (MONW) individuals are not obese in terms of weight and height but have a number of obesity-related features (e.g. greater visceral adiposity, insulin resistance, and increas...

    Authors: Margalida Cifre, Andreu Palou and Paula Oliver

    Citation: Molecular Neurodegeneration 2018 13:14

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  7. Content type: Research article

    We have evaluated the efficacy of targeting the toxic, oligomeric form of tau protein by passive immunotherapy in a mouse model of synucleinopathy. Parkinson’s disease and Lewy body dementia are two of the mos...

    Authors: Julia E. Gerson, Kathleen M. Farmer, Natalie Henson, Diana L. Castillo-Carranza, Mariana Carretero Murillo, Urmi Sengupta, Alan Barrett and Rakez Kayed

    Citation: Molecular Neurodegeneration 2018 13:13

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  8. Content type: Research article

    Degeneration of cone photoreceptors leads to loss of vision in patients suffering from age-related macular degeneration (AMD) and other cone dystrophies. Evidence, such as choroidal ischemia and decreased chor...

    Authors: Maya Barben, Christian Schori, Marijana Samardzija and Christian Grimm

    Citation: Molecular Neurodegeneration 2018 13:12

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  9. Content type: Research article

    Dynactin p150Glued, the largest subunit of the dynactin macromolecular complex, binds to both microtubules and tubulin dimers through the N-terminal cytoskeleton-associated protein and glycine-rich (CAP-Gly) and ...

    Authors: Jia Yu, Chen Lai, Hoon Shim, Chengsong Xie, Lixin Sun, Cai-Xia Long, Jinhui Ding, Yan Li and Huaibin Cai

    Citation: Molecular Neurodegeneration 2018 13:10

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  10. Content type: Research article

    Besides the two main classical features of amyloid beta aggregation and tau-containing neurofibrillary tangle deposition, neuroinflammation plays an important yet unclear role in the pathophysiology of Alzheim...

    Authors: Justyna Sosna, Stephan Philipp, Ricardo Albay III, Jorge Mauricio Reyes-Ruiz, David Baglietto-Vargas, Frank M. LaFerla and Charles G. Glabe

    Citation: Molecular Neurodegeneration 2018 13:11

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  11. Content type: Research article

    Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson’s disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that m...

    Authors: Ga Ram Jeong, Eun-Hae Jang, Jae Ryul Bae, Soyoung Jun, Ho Chul Kang, Chi-Hu Park, Joo-Ho Shin, Yukio Yamamoto, Keiko Tanaka-Yamamoto, Valina L. Dawson, Ted M. Dawson, Eun-Mi Hur and Byoung Dae Lee

    Citation: Molecular Neurodegeneration 2018 13:8

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  12. Content type: Research article

    Progressive neuron loss in the frontal and temporal lobes of the cerebral cortex typifies frontotemporal lobar degeneration (FTLD). FTLD sub types are classified on the basis of neuronal aggregated protein dep...

    Authors: Laura M. Taylor, Pamela J. McMillan, Nicole F. Liachko, Timothy J. Strovas, Bernardino Ghetti, Thomas D. Bird, C. Dirk Keene and Brian C. Kraemer

    Citation: Molecular Neurodegeneration 2018 13:7

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  13. Content type: Research article

    β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patie...

    Authors: WonHee Kim, Liang Ma, Selene Lomoio, Rachel Willen, Sylvia Lombardo, Jinghui Dong, Philip G. Haydon and Giuseppina Tesco

    Citation: Molecular Neurodegeneration 2018 13:6

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  14. Content type: Research article

    Mitochondria are the organelles responsible for energy metabolism and have a direct impact on neuronal function and survival. Mitochondrial abnormalities have been well characterized in Alzheimer Disease (AD)....

    Authors: Sirui Jiang, Priya Nandy, Wenzhang Wang, Xiaopin Ma, Jeffrey Hsia, Chunyu Wang, Zhenlian Wang, Mengyue Niu, Sandra L. Siedlak, Sandy Torres, Hisashi Fujioka, Ying Xu, Hyoung-gon Lee, George Perry, Jun Liu and Xiongwei Zhu

    Citation: Molecular Neurodegeneration 2018 13:5

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  15. Content type: Research article

    Spinocerebellar ataxia 17 (SCA17) belongs to the family of neurodegenerative diseases caused by polyglutamine (polyQ) expansion. In SCA17, polyQ expansion occurs in the TATA box binding protein (TBP) and leads...

    Authors: Jifeng Guo, Yiting Cui, Qiong Liu, Yang Yang, Yujing Li, Ling Weng, Beisha Tang, Peng Jin, Xiao-Jiang Li, Su Yang and Shihua Li

    Citation: Molecular Neurodegeneration 2018 13:4

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  16. Content type: Research article

    Mutations in LRRK2 are a common genetic cause of Parkinson’s disease (PD). LRRK2 interacts with and phosphorylates a subset of Rab proteins including Rab8a, a protein which has been implicated in various centr...

    Authors: Jesús Madero-Pérez, Elena Fdez, Belén Fernández, Antonio J. Lara Ordóñez, Marian Blanca Ramírez, Patricia Gómez-Suaga, Dieter Waschbüsch, Evy Lobbestael, Veerle Baekelandt, Angus C. Nairn, Javier Ruiz-Martínez, Ana Aiastui, Adolfo López de Munain, Pawel Lis, Thomas Comptdaer, Jean-Marc Taymans…

    Citation: Molecular Neurodegeneration 2018 13:3

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  17. Content type: Research article

    Alzheimer’s disease (AD), the most common neurodegenerative disorder, is characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tangles. To understand the pathologic...

    Authors: Dong Kyu Kim, Joonho Park, Dohyun Han, Jinhee Yang, Ahbin Kim, Jongmin Woo, Youngsoo Kim and Inhee Mook-Jung

    Citation: Molecular Neurodegeneration 2018 13:2

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  18. Content type: Research article

    Mutations in glucocerebrosidase (GBA) cause Gaucher disease (GD) and increase the risk of developing Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). Since both genetic and environmental factors c...

    Authors: Seung Pil Yun, Donghoon Kim, Sangjune Kim, SangMin Kim, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Saebom Lee, Tae-In Kam, Suhyun Lee, Sangwoo Ham, Jae Hong Park, Valina L. Dawson, Ted M. Dawson, Yunjong Lee and Han Seok Ko

    Citation: Molecular Neurodegeneration 2018 13:1

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  19. Content type: Research article

    The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggrega...

    Authors: Maria Joseph, Marta Anglada-Huguet, Katharina Paesler, Eckhard Mandelkow and Eva-Maria Mandelkow

    Citation: Molecular Neurodegeneration 2017 12:88

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  20. Content type: Research article

    Tau is a microtubule-binding protein, which is subject to various post-translational modifications (PTMs) including phosphorylation, methylation, acetylation, glycosylation, nitration, sumoylation and truncati...

    Authors: Ebru Ercan, Sameh Eid, Christian Weber, Alexandra Kowalski, Maria Bichmann, Annika Behrendt, Frank Matthes, Sybille Krauss, Peter Reinhardt, Simone Fulle and Dagmar E. Ehrnhoefer

    Citation: Molecular Neurodegeneration 2017 12:87

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  21. Content type: Research article

    Alzheimer’s disease (AD) is characterized by amyloid deposition, tangle formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of AD. Identifying early synaptic abnormalities...

    Authors: Yang Bai, Miao Li, Yanmei Zhou, Lei Ma, Qian Qiao, Wanling Hu, Wei Li, Zachary Patrick Wills and Wen-Biao Gan

    Citation: Molecular Neurodegeneration 2017 12:86

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  22. Content type: Review

    Parkinson’s disease (PD) is a progressive movement neurodegenerative disease associated with a loss of dopaminergic neurons in the substantia nigra of the brain. Oxidative stress, a condition that occurs due t...

    Authors: Karim Belarbi, Elodie Cuvelier, Alain Destée, Bernard Gressier and Marie-Christine Chartier-Harlin

    Citation: Molecular Neurodegeneration 2017 12:84

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