Skip to main content

Articles

Page 1 of 21

  1. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xue Wang, Mariet Allen, Shaoyu Li, Zachary S. Quicksall, Tulsi A. Patel, Troy P. Carnwath, Joseph S. Reddy, Minerva M. Carrasquillo, Sarah J. Lincoln, Thuy T. Nguyen, Kimberly G. Malphrus, Dennis W. Dickson, Julia E. Crook, Yan W. Asmann and Nilüfer Ertekin-Taner

    Citation: Molecular Neurodegeneration 2020 15:54

    Content type: Correction

    Published on:

    The original article was published in Molecular Neurodegeneration 2020 15:38

  2. Alzheimer’s disease (AD) is the most frequent and costly neurodegenerative disorder. Although diverse lines of evidence suggest that the amyloid precursor protein (APP) is involved in its causation, the precis...

    Authors: Erik C. B. Johnson, Kaitlyn Ho, Gui-Qiu Yu, Melanie Das, Pascal E. Sanchez, Biljana Djukic, Isabel Lopez, Xinxing Yu, Michael Gill, Weiping Zhang, Jeanne T. Paz, Jorge J. Palop and Lennart Mucke

    Citation: Molecular Neurodegeneration 2020 15:53

    Content type: Research article

    Published on:

  3. Microglia-specific genetic variants are enriched in several neurodegenerative diseases, including Alzheimer’s disease (AD), implicating a central role for alterations of the innate immune system in the disease...

    Authors: Mari Takalo, Rebekka Wittrahm, Benedikt Wefers, Samira Parhizkar, Kimmo Jokivarsi, Teemu Kuulasmaa, Petra Mäkinen, Henna Martiskainen, Wolfgang Wurst, Xianyuan Xiang, Mikael Marttinen, Pekka Poutiainen, Annakaisa Haapasalo, Mikko Hiltunen and Christian Haass

    Citation: Molecular Neurodegeneration 2020 15:52

    Content type: Short report

    Published on:

  4. Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in motor neurons of almost all amyotrophic lateral sclerosis (ALS) patients, and mutations in TDP-43 are also present in ALS. Loss and gain...

    Authors: Anna Konopka, Donna R. Whelan, Md Shafi Jamali, Emma Perri, Hamideh Shahheydari, Reka P. Toth, Sonam Parakh, Tina Robinson, Alison Cheong, Prachi Mehta, Marta Vidal, Audrey M. G. Ragagnin, Ivan Khizhnyak, Cyril J. Jagaraj, Jasmin Galper, Natalie Grima…

    Citation: Molecular Neurodegeneration 2020 15:51

    Content type: Research article

    Published on:

  5. Disruption of β-amyloid (Aβ) homeostasis is the initial culprit in Alzheimer’s disease (AD) pathogenesis. Astrocytes respond to emerging Aβ plaques by altering their phenotype and function, yet molecular mecha...

    Authors: Joanna E. Pankiewicz, Jenny R. Diaz, Mitchell Martá-Ariza, Anita M. Lizińczyk, Leor A. Franco and Martin J. Sadowski

    Citation: Molecular Neurodegeneration 2020 15:50

    Content type: Research article

    Published on:

  6. α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson’s disease (PD). Mouse aSyn contains a threonine residue at position...

    Authors: Natalie Landeck, Katherine E. Strathearn, Daniel Ysselstein, Kerstin Buck, Sayan Dutta, Siddhartha Banerjee, Zhengjian Lv, John D. Hulleman, Jagadish Hindupur, Li-Kai Lin, Sonal Padalkar, Lia A. Stanciu, Yuri L. Lyubchenko, Deniz Kirik and Jean-Christophe Rochet

    Citation: Molecular Neurodegeneration 2020 15:49

    Content type: Research article

    Published on:

  7. Glaucoma is a leading neurodegenerative disease affecting over 70 million individuals worldwide. Early pathological events of axonal degeneration and retinopathy in response to elevated intraocular pressure (I...

    Authors: Prabhavathi Maddineni, Ramesh B. Kasetti, Pinkal D. Patel, J. Cameron Millar, Charles Kiehlbauch, Abbot F. Clark and Gulab S. Zode

    Citation: Molecular Neurodegeneration 2020 15:48

    Content type: Research article

    Published on:

  8. Neuronal accumulation of misfolded microtubule-associated protein tau is a hallmark of neuropathology in Alzheimer’s disease, frontotemporal dementia, and other tauopathies, and has been a therapeutic target. ...

    Authors: Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Alicia A. Van Enoo, Jianqiao Hu, Seiko Ikezu and Tsuneya Ikezu

    Citation: Molecular Neurodegeneration 2020 15:47

    Content type: Research article

    Published on:

  9. Alzheimer’s disease (AD) is the major cause of death in adults with Down syndrome (DS). There is an urgent need for objective markers of AD in the DS population to improve early diagnosis and monitor disease p...

    Authors: Olivia Belbin, Mei-Fang Xiao, Desheng Xu, Maria Carmona-Iragui, Jordi Pegueroles, Bessy Benejam, Laura Videla, Susana Fernández, Isabel Barroeta, Raúl Nuñez-Llaves, Victor Montal, Eduard Vilaplana, Miren Altuna, Jordi Clarimón, Daniel Alcolea, Rafael Blesa…

    Citation: Molecular Neurodegeneration 2020 15:46

    Content type: Research article

    Published on:

  11. Identified as an Alzheimer’s disease (AD) susceptibility gene by genome wide-association studies, BIN1 has 10 isoforms that are expressed in the Central Nervous System (CNS). The distribution of these isoforms in...

    Authors: Mariko Taga, Vladislav A. Petyuk, Charles White, Galina Marsh, Yiyi Ma, Hans-Ulrich Klein, Sarah M. Connor, Alexandra Kroshilina, Christina J. Yung, Anthony Khairallah, Marta Olah, Julie Schneider, Kyle Karhohs, Anne E. Carpenter, Richard Ransohoff, David A. Bennett…

    Citation: Molecular Neurodegeneration 2020 15:44

    Content type: Research article

    Published on:

  12. Based on amyloid cascade and tau hypotheses, protein biomarkers of different Aβ and tau species in cerebrospinal fluid (CSF) and blood/plasma/serum have been examined to correlate with brain pathology. Recentl...

    Authors: Hong Wang, Kaushik Kumar Dey, Ping-Chung Chen, Yuxin Li, Mingming Niu, Ji-Hoon Cho, Xusheng Wang, Bing Bai, Yun Jiao, Surendhar Reddy Chepyala, Vahram Haroutunian, Bin Zhang, Thomas G. Beach and Junmin Peng

    Citation: Molecular Neurodegeneration 2020 15:43

    Content type: Research article

    Published on:

  13. Alzheimer disease (AD) is the most prominent form of dementia and the 5th leading cause of death in individuals over 65. AD is a complex disease stemming from genetic, environmental, and lifestyle factors. It ...

    Authors: Hannah R. Bulgart, Evan W. Neczypor, Loren E. Wold and Amy R. Mackos

    Citation: Molecular Neurodegeneration 2020 15:42

    Content type: Review

    Published on:

  14. Alzheimer’s Disease (AD) is a neurodegenerative disorder influenced by aging and genetic risk factors. The inheritance of APOEε4 and variants of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) are major ...

    Authors: Nicholas F. Fitz, Cody M. Wolfe, Brittany E. Playso, Richard J. Biedrzycki, Yi Lu, Kyong Nyon Nam, Iliya Lefterov and Radosveta Koldamova

    Citation: Molecular Neurodegeneration 2020 15:41

    Content type: Research article

    Published on:

  15. Alzheimer’s disease (AD) is the most common neurodegenerative disorder seen in age-dependent dementia. There is currently no effective treatment for AD, which may be attributed in part to lack of a clear under...

    Authors: Tiantian Guo, Denghong Zhang, Yuzhe Zeng, Timothy Y. Huang, Huaxi Xu and Yingjun Zhao

    Citation: Molecular Neurodegeneration 2020 15:40

    Content type: Review

    Published on:

  16. Tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of several Tauopathies, including Alzheimer Disease (AD). Trans-cellular propagation of Tau with pathological conformation ha...

    Authors: Senthilvelrajan Kaniyappan, Katharina Tepper, Jacek Biernat, Ram Reddy Chandupatla, Sabrina Hübschmann, Stephan Irsen, Sandra Bicher, Christoph Klatt, Eva-Maria Mandelkow and Eckhard Mandelkow

    Citation: Molecular Neurodegeneration 2020 15:39

    Content type: Research article

    Published on:

  17. Large-scale brain bulk-RNAseq studies identified molecular pathways implicated in Alzheimer’s disease (AD), however these findings can be confounded by cellular composition changes in bulk-tissue. To identify ...

    Authors: Xue Wang, Mariet Allen, Shaoyu Li, Zachary S. Quicksall, Tulsi A. Patel, Troy P. Carnwath, Joseph S. Reddy, Minerva M. Carrasquillo, Sarah J. Lincoln, Thuy T. Nguyen, Kimberly G. Malphrus, Dennis W. Dickson, Julia E. Crook, Yan W. Asmann and Nilüfer Ertekin-Taner

    Citation: Molecular Neurodegeneration 2020 15:38

    Content type: Research article

    Published on:

    The Correction to this article has been published in Molecular Neurodegeneration 2020 15:54

  18. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiaoqiang Tang, Arturo Toro, T. G. Sahana, Junli Gao, Jessica Chalk, Björn Oskarsson and Ke Zhang

    Citation: Molecular Neurodegeneration 2020 15:37

    Content type: Correction

    Published on:

    The original article was published in Molecular Neurodegeneration 2020 15:34

  19. Diagnosis of dementia with Lewy bodies (DLB) is challenging, largely due to a lack of diagnostic tools. Cerebrospinal fluid (CSF) biomarkers have been proven useful in Alzheimer’s disease (AD) diagnosis. Here,...

    Authors: Inger van Steenoven, Marleen J. A. Koel-Simmelink, Leonie J. M. Vergouw, Betty M. Tijms, Sander R. Piersma, Thang V. Pham, Claire Bridel, Gian-Luca Ferri, Cristina Cocco, Barbara Noli, Paul F. Worley, Mei-Fang Xiao, Desheng Xu, Patrick Oeckl, Markus Otto, Wiesje M. van der Flier…

    Citation: Molecular Neurodegeneration 2020 15:36

    Content type: Research article

    Published on:

  20. The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes structural and functional alterations in normal brains, and is the strongest genetic risk factor of the sp...

    Authors: Raquel Larramona-Arcas, Candela González-Arias, Gertrudis Perea, Antonia Gutiérrez, Javier Vitorica, Tamara García-Barrera, José Luis Gómez-Ariza, Raquel Pascua-Maestro, María Dolores Ganfornina, Eleanna Kara, Eloise Hudry, Marta Martinez-Vicente, Miquel Vila, Elena Galea and Roser Masgrau

    Citation: Molecular Neurodegeneration 2020 15:35

    Content type: Research article

    Published on:

  21. Ever since a GGGGCC hexanucleotide repeat expansion mutation in C9ORF72 was identified as the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), three competing b...

    Authors: Xiaoqiang Tang, Arturo Toro, Sahana T.G., Junli Gao, Jessica Chalk, Björn E. Oskarsson and Ke Zhang

    Citation: Molecular Neurodegeneration 2020 15:34

    Content type: Review

    Published on:

    The Correction to this article has been published in Molecular Neurodegeneration 2020 15:37

  22. The main motor subtypes of Parkinson’s disease (PD) include tremor-dominant (TD) and postural instability gait disorder (PIGD), with varying disease course that warrant the development of biomarkers capable of...

    Authors: Adeline Su Lyn Ng, Yi Jayne Tan, Alisa Cui Wen Yong, Seyed Ehsan Saffari, Zhonghao Lu, Ebonne Yulin Ng, Samuel Yong Ern Ng, Nicole Shuang Yu Chia, Xinyi Choi, Dede Heng, Shermyn Neo, Zheyu Xu, Nicole Chwee Har Keong, Kay Yaw Tay, Wing Lok Au, Louis Chew Seng Tan…

    Citation: Molecular Neurodegeneration 2020 15:33

    Content type: Research article

    Published on:

  23. Emerging evidence demonstrates that adaptive immunity influences the pathobiology of neurodegenerative disorders. Misfolded aggregated self-proteins can break immune tolerance leading to the induction of autor...

    Authors: Jatin Machhi, Bhavesh D. Kevadiya, Ijaz Khan Muhammad, Jonathan Herskovitz, Katherine E. Olson, R. Lee Mosley and Howard E. Gendelman

    Citation: Molecular Neurodegeneration 2020 15:32

    Content type: Review

    Published on:

  24. Amyotrophic lateral sclerosis (ALS) and Frontotemporal Degeneration (FTD) are neurodegenerative disorders, related by deterioration of motor and cognitive functions and short survival. Aside from cases with an...

    Authors: Rajka Maria Liscic, Antonella Alberici, Nigel John Cairns, Maurizio Romano and Emanuele Buratti

    Citation: Molecular Neurodegeneration 2020 15:31

    Content type: Review

    Published on:

  25. Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by impaired cognitive function due to progressive loss of neurons in the brain. Under the microscope, neuronal ac...

    Authors: Wenzhang Wang, Fanpeng Zhao, Xiaopin Ma, George Perry and Xiongwei Zhu

    Citation: Molecular Neurodegeneration 2020 15:30

    Content type: Review

    Published on:

  26. Huntington’s disease (HD) is an incurable neurodegenerative disorder caused by CAG trinucleotide expansions in the huntingtin gene. Markers of both systemic and CNS immune activation and inflammation have been wi...

    Authors: Mary H. Wertz, S. Sebastian Pineda, Hyeseung Lee, Ruth Kulicke, Manolis Kellis and Myriam Heiman

    Citation: Molecular Neurodegeneration 2020 15:29

    Content type: Short report

    Published on:

  27. Proteomic characterization of microglia provides the most proximate assessment of functionally relevant molecular mechanisms of neuroinflammation. However, microglial proteomics studies have been limited by lo...

    Authors: Sruti Rayaprolu, Tianwen Gao, Hailian Xiao, Supriya Ramesha, Laura D. Weinstock, Jheel Shah, Duc M. Duong, Eric B. Dammer, James A. Webster Jr, James J. Lah, Levi B. Wood, Ranjita Betarbet, Allan I. Levey, Nicholas T. Seyfried and Srikant Rangaraju

    Citation: Molecular Neurodegeneration 2020 15:28

    Content type: Research article

    Published on:

  28. Studies link c-Abl activation with the accumulation of pathogenic α-synuclein (αS) and neurodegeneration in Parkinson’s disease (PD). Currently, c-Abl, a tyrosine kinase activated by cellular stress, is though...

    Authors: Md. Razaul Karim, Elly E. Liao, Jaekwang Kim, Joyce Meints, Hector Martell Martinez, Olga Pletnikova, Juan C. Troncoso and Michael K. Lee

    Citation: Molecular Neurodegeneration 2020 15:27

    Content type: Research article

    Published on:

  29. Acute glaucoma, characterized by a sudden elevation in intraocular pressure (IOP) and retinal ganglion cells (RGCs) death, is a major cause of irreversible blindness worldwide that lacks approved effective the...

    Authors: Hui Chen, Yang Deng, Xiaoliang Gan, Yonghao Li, Wenyong Huang, Lin Lu, Lai Wei, Lishi Su, Jiawen Luo, Bin Zou, Yanhua Hong, Yihai Cao, Yizhi Liu and Wei Chi

    Citation: Molecular Neurodegeneration 2020 15:26

    Content type: Research article

    Published on:

  30. Loss of function of triggering receptor expressed on myeloid cell 2 (TREM2), a key receptor selectively expressed by microglia in the brain, contributes to the development of Alzheimer’s disease (AD). Whether ...

    Authors: Ling-Zhi Ma, Lan Tan, Yan-Lin Bi, Xue-Ning Shen, Wei Xu, Ya-Hui Ma, Hong-Qi Li, Qiang Dong and Jin-Tai Yu

    Citation: Molecular Neurodegeneration 2020 15:25

    Content type: Research article

    Published on:

  31. α-Synuclein (α-Syn) is a protein implicated in the pathogenesis of Parkinson’s disease (PD). α-Syn has been shown to associate with membranes and bind acidic phospholipids. However, the physiological importanc...

    Authors: Meir Schechter, Jessica Grigoletto, Suaad Abd-Elhadi, Hava Glickstein, Alexander Friedman, Geidy E. Serrano, Thomas G. Beach and Ronit Sharon

    Citation: Molecular Neurodegeneration 2020 15:24

    Content type: Research article

    Published on:

  32. Several lines of evidence suggest that high-density lipoprotein (HDL) reduces Alzheimer’s disease (AD) risk by decreasing vascular beta-amyloid (Aβ) deposition and inflammation, however, the mechanisms by whic...

    Authors: Jerome Robert, Emily B. Button, Emma M. Martin, Luke McAlary, Zoe Gidden, Megan Gilmour, Guilaine Boyce, Tara M. Caffrey, Andrew Agbay, Amanda Clark, Judith M. Silverman, Neil R. Cashman and Cheryl L. Wellington

    Citation: Molecular Neurodegeneration 2020 15:23

    Content type: Research article

    Published on:

  33. The original article had mistakenly inverted co-author, Wang Zheng’s name. This has since been corrected.

    Authors: Xi Chen, Chengsong Xie, Wotu Tian, Lixin Sun, Wang Zheng, Sarah Hawes, Lisa Chang, Justin Kung, Jinhui Ding, Shengdi Chen, Weidong Le and Huaibin Cai

    Citation: Molecular Neurodegeneration 2020 15:22

    Content type: Correction

    Published on:

    The original article was published in Molecular Neurodegeneration 2020 15:12

  34. Frontotemporal lobar degeneration (FTLD) is a devastating and progressive disorder, and a common cause of early onset dementia. Progranulin (PGRN) haploinsufficiency due to autosomal dominant mutations in the ...

    Authors: Jonathan Frew, Alireza Baradaran-Heravi, Aruna D. Balgi, Xiujuan Wu, Tyler D. Yan, Steve Arns, Fahimeh S. Shidmoossavee, Jason Tan, James B. Jaquith, Karen R. Jansen-West, Francis C. Lynn, Fen-Biao Gao, Leonard Petrucelli, Howard H. Feldman, Ian R. Mackenzie, Michel Roberge…

    Citation: Molecular Neurodegeneration 2020 15:21

    Content type: Research article

    Published on:

  35. That certain cell types in the central nervous system are more likely to undergo neurodegeneration in Parkinson’s disease is a widely appreciated but poorly understood phenomenon. Many vulnerable subpopulation...

    Authors: Preston Ge, Valina L. Dawson and Ted M. Dawson

    Citation: Molecular Neurodegeneration 2020 15:20

    Content type: Review

    Published on:

  37. Mutations in PINK1 and parkin cause autosomal recessive Parkinson’s disease (PD). Evidence placing PINK1 and parkin in common pathways regulating multiple aspects of mitochondrial quality control is burgeoning...

    Authors: Sheila K. Pirooznia, Changqing Yuan, Mohammed Repon Khan, Senthilkumar S. Karuppagounder, Luan Wang, Yulan Xiong, Sung Ung Kang, Yunjong Lee, Valina L. Dawson and Ted M. Dawson

    Citation: Molecular Neurodegeneration 2020 15:17

    Content type: Research article

    Published on:

  38. Recombinant adeno-associated virus (rAAV) is widely used in the neuroscience field to manipulate gene expression in the nervous system. However, a limitation to the use of rAAV vectors is the time and expense ...

    Authors: Marshall S. Goodwin, Cara L. Croft, Hunter S. Futch, Daniel Ryu, Carolina Ceballos-Diaz, Xuefei Liu, Giavanna Paterno, Catalina Mejia, Doris Deng, Kimberly Menezes, Laura Londono, Kefren Arjona, Mary Parianos, Van Truong, Eva Rostonics, Amanda Hernandez…

    Citation: Molecular Neurodegeneration 2020 15:15

    Content type: Methodology

    Published on:

  39. The C9ORF72 hexanucleotide repeat expansion is the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two fatal age-related neurodegenerative diseases. Th...

    Authors: Nadja S. Andrade, Melina Ramic, Rustam Esanov, Wenjun Liu, Mathew J. Rybin, Gabriel Gaidosh, Abbas Abdallah, Samuel Del’Olio, Tyler C. Huff, Nancy T. Chee, Sadhana Anatha, Tania F. Gendron, Claes Wahlestedt, Yanbin Zhang, Michael Benatar, Christian Mueller…

    Citation: Molecular Neurodegeneration 2020 15:13

    Content type: Research article

    Published on:

  40. Multiple missense mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with familial forms of late onset Parkinson’s disease (PD), the most common age-related movement disorder. The dysfunction of ...

    Authors: Xi Chen, Chengsong Xie, Wotu Tian, Lixin Sun, Wang Zheng, Sarah Hawes, Lisa Chang, Justin Kung, Jinhui Ding, Shengdi Chen, Weidong Le and Huaibin Cai

    Citation: Molecular Neurodegeneration 2020 15:12

    Content type: Research article

    Published on:

    The Correction to this article has been published in Molecular Neurodegeneration 2020 15:22

  41. Several studies have linked circulating cell-free mitochondrial DNA (ccf-mtDNA) to human disease. In particular, reduced ccf-mtDNA levels in the cerebrospinal fluid (CSF) of both Alzheimer’s and Parkinson’s di...

    Authors: Hannah Lowes, Angela Pyle, Mauro Santibanez-Koref and Gavin Hudson

    Citation: Molecular Neurodegeneration 2020 15:10

    Content type: Short report

    Published on:

  43. A repeat expansion in the C9orf72-SMCR8 complex subunit (C9orf72) is the most common genetic cause of two debilitating neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (...

    Authors: Jazmyne L. Jackson, NiCole A. Finch, Matthew C. Baker, Jennifer M. Kachergus, Mariely DeJesus-Hernandez, Kimberly Pereira, Elizabeth Christopher, Mercedes Prudencio, Michael G. Heckman, E. Aubrey Thompson, Dennis W. Dickson, Jaimin Shah, Björn Oskarsson, Leonard Petrucelli, Rosa Rademakers and Marka van Blitterswijk

    Citation: Molecular Neurodegeneration 2020 15:7

    Content type: Research article

    Published on:

  44. The vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex system, an ubiquitous multiprotein assembly responsible for sorting and trafficking protein cargos out of the endosomes. VPS...

    Authors: Jian-Guo Li, Jin Chiu, Mercy Ramanjulu, Benjamin E. Blass and Domenico Praticò

    Citation: Molecular Neurodegeneration 2020 15:1

    Content type: Research article

    Published on:

  45. The original article [1] contains an error in the y-axes of Fig. 8’s sub-figures whereby ‘CSF’ is mistakenly mentioned instead of ‘serum’.

    Authors: Mylene Huebecker, Elizabeth B. Moloney, Aarnoud C. van der Spoel, David A. Priestman, Ole Isacson, Penelope J. Hallett and Frances M. Platt

    Citation: Molecular Neurodegeneration 2020 15:6

    Content type: Correction

    Published on:

    The original article was published in Molecular Neurodegeneration 2019 14:40

  46. Misfolding and aggregation of the presynaptic protein alpha-synuclein (αsyn) is a hallmark of Parkinson’s disease (PD) and related synucleinopathies. Although predominantly localized in the cytosol, a body of ...

    Authors: Jae-Hyeon Park, Jeremy D. Burgess, Ayman H. Faroqi, Natasha N. DeMeo, Fabienne C. Fiesel, Wolfdieter Springer, Marion Delenclos and Pamela J. McLean

    Citation: Molecular Neurodegeneration 2020 15:5

    Content type: Research article

    Published on:

  47. Multiomic studies by several groups in the NIH Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) identified VGF as a major driver of Alzheimer’s disease (AD), also finding that reduced VGF le...

    Authors: Farida El Gaamouch, Mickael Audrain, Wei-Jye Lin, Noam Beckmann, Cheng Jiang, Siddharth Hariharan, Peter S. Heeger, Eric E. Schadt, Sam Gandy, Michelle E. Ehrlich and Stephen R. Salton

    Citation: Molecular Neurodegeneration 2020 15:4

    Content type: Research article

    Published on:

  48. The amyloid-β (Aβ) peptide, the primary constituent of amyloid plaques found in Alzheimer’s disease (AD) brains, is derived from sequential proteolytic processing of the Amyloid Precursor Protein (APP). Howeve...

    Authors: Heather C. Rice, Gabriele Marcassa, Iordana Chrysidou, Katrien Horré, Tracy L. Young-Pearse, Ulrike C. Müller, Takashi Saito, Takaomi C. Saido, Robert Vassar, Joris de Wit and Bart De Strooper

    Citation: Molecular Neurodegeneration 2020 15:3

    Content type: Short report

    Published on:

  49. The trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how tha...

    Authors: Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Michelle Arkin, Ana Maria Cuervo and Li Gan

    Citation: Molecular Neurodegeneration 2020 15:2

    Content type: Research article

    Published on:

  50. Previous studies regarding the cholesterol-cognition relationship in midlife have generated conflicting results. We thus investigated whether dietary and blood cholesterol were associated with cognitive decline.

    Authors: Yu An, Xiaona Zhang, Ying Wang, Yushan Wang, Wen Liu, Tao Wang, Zhongsheng Qin and Rong Xiao

    Citation: Molecular Neurodegeneration 2019 14:51

    Content type: Research article

    Published on:

Submit manuscript

Follow

  • ISSN: 1750-1326 (electronic)

Molecular Neurodegeneration

ISSN: 1750-1326