Articles

Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

The role of viral infection in Alzheimer Disease (AD) pathogenesis is an area of great interest in recent years. Several studies have suggested an association between the human roseoloviruses, HHV-6 and HHV-7,...

Authors: Tarin M. Bigley, Monica Xiong, Muhammad Ali, Yun Chen, Chao Wang, Javier Remolina Serrano, Abdallah Eteleeb, Oscar Harari, Liping Yang, Swapneel J. Patel, Carlos Cruchaga, Wayne M. Yokoyama and David M. Holtzman

Dynamic changes of CSF sPDGFRβ during ageing and AD progression and associations with CSF ATN biomarkers

Loss of brain capillary pericyte is involved in the pathologies and cognitive deficits in Alzheimer’s disease (AD). The role of pericyte in early stage of AD pathogenesis remains unclear.

Authors: Jun Wang, Dong-Yu Fan, Hui-Yun Li, Chen-Yang He, Ying-Ying Shen, Gui-Hua Zeng, Dong-Wan Chen, Xu Yi, Ya-Hui Ma, Jin-Tai Yu and Yan-Jiang Wang

Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells

Spinal cord motor neurons (MNs) from human iPS cells (iPSCs) have wide applications in disease modeling and therapeutic development for amyotrophic lateral sclerosis (ALS) and other MN-associated neurodegenera...

Authors: Qian Li, Yi Feng, Yingchao Xue, Xiping Zhan, Yi Fu, Gege Gui, Weiqiang Zhou, Jean-Philippe Richard, Arens Taga, Pan Li, Xiaobo Mao, Nicholas J. Maragakis and Mingyao Ying

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson’s disease (PD). Aggregated α-synuclein pathologically defines PD. Recent studies identified elevated LRRK2 expression i...

Authors: Enquan Xu, Ravindra Boddu, Hisham A. Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M. Carlisle, Elliot J. Lefkowitz, Ashley S. Harms, Etty N. Benveniste, Talene A. Yacoubian, Laura A. Volpicelli-Daley, David G. Standaert and Andrew B. West

A novel H129-based anterograde monosynaptic tracer exhibits features of strong labeling intensity, high tracing efficiency, and reduced retrograde labeling

Viral tracers are important tools for mapping brain connectomes. The feature of predominant anterograde transneuronal transmission offers herpes simplex virus-1 (HSV-1) strain H129 (HSV1-H129) as a promising c...

Authors: Hong Yang, Feng Xiong, Hai-Bin Qin, Qun-Tao Yu, Jin-Yan Sun, Hai-Wen Zhao, Dong Li, Youtong Zhou, Fu-Kun Zhang, Xiao-Wen Zhu, Tong Wu, Man Jiang, Xiangmin Xu, Youming Lu, Hong-Jie Shen, Wen-Bo Zeng…

The landscape of human tissue and cell type specific expression and co-regulation of senescence genes

Cellular senescence is a complex stress response that impacts cellular function and organismal health. Multiple developmental and environmental factors, such as intrinsic cellular cues, radiation, oxidative st...

Authors: Peng Xu, Minghui Wang, Won-min Song, Qian Wang, Guo-Cheng Yuan, Peter H. Sudmant, Habil Zare, Zhidong Tu, Miranda E. Orr and Bin Zhang

The role of inflammasomes in vascular cognitive impairment

There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical role in disease onset and progr...

Authors: Luting Poh, Wei Liang Sim, Dong-Gyu Jo, Quynh Nhu Dinh, Grant R. Drummond, Christopher G. Sobey, Christopher Li-Hsian Chen, Mitchell K. P. Lai, David Y. Fann and Thiruma V. Arumugam

Challenge accepted: uncovering the role of rare genetic variants in Alzheimer’s disease

The search for rare variants in Alzheimer’s disease (AD) is usually deemed a high-risk - high-reward situation. The challenges associated with this endeavor are real. Still, the application of genome-wide tech...

Authors: Marzieh Khani, Elizabeth Gibbons, Jose Bras and Rita Guerreiro

Sleep and circadian rhythms in Parkinson’s disease and preclinical models

The use of animals as models of human physiology is, and has been for many years, an indispensable tool for understanding the mechanisms of human disease. In Parkinson’s disease, various mouse models form the ...

Authors: Jeremy Hunt, Elizabeth J. Coulson, Rajendram Rajnarayanan, Henrik Oster, Aleksandar Videnovic and Oliver Rawashdeh

Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients

In response to injury, neurons activate a program of organized axon self-destruction initiated by the NAD⁺ hydrolase, SARM1. In healthy neurons SARM1 is autoinhibited, but single amino acid changes can abolish au...

Authors: A. Joseph Bloom, Xianrong Mao, Amy Strickland, Yo Sasaki, Jeffrey Milbrandt and Aaron DiAntonio

TDP-43 Pathology in Alzheimer’s Disease

Transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein encoded by the TARDBP gene that is involved in RNA splicing, trafficking, stabilization, and thus, the regulation of gene exp...

Authors: Axel Meneses, Shunsuke Koga, Justin O’Leary, Dennis W. Dickson, Guojun Bu and Na Zhao

Neuropathology and molecular diagnosis of Synucleinopathies

Synucleinopathies are clinically and pathologically heterogeneous disorders characterized by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies, Lewy neurites, neuronal cytopl...

Authors: Shunsuke Koga, Hiroaki Sekiya, Naveen Kondru, Owen A. Ross and Dennis W. Dickson

Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories

Detection of the pathological and disease-associated alpha-synuclein (αSyn^D) in the brain is required to formulate the definitive diagnosis of multiple system atrophy (MSA) and Parkinson’s disease (PD). We recent...

Authors: Connor Bargar, Chiara Maria Giulia De Luca, Grazia Devigili, Antonio Emanuele Elia, Roberto Cilia, Sara Maria Portaleone, Wen Wang, Irene Tramacere, Edoardo Bistaffa, Federico Angelo Cazzaniga, Giovanni Felisati, Giuseppe Legname, Alessio Di Fonzo, Rong Xu, Steven Alexander Gunzler, Giorgio Giaccone…

Basal lamina changes in neurodegenerative disorders

Neurodegenerative disorders are a group of age-associated diseases characterized by progressive degeneration of the structure and function of the CNS. Two key pathological features of these disorders are blood...

Authors: Benjamin Nguyen, Gregory Bix and Yao Yao

MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

MicroRNA (miRNA) expression in the brain is altered in neurodegenerative diseases. Recent studies demonstrated that selected miRNAs conventionally regulating gene expression at the post-transcriptional level c...

Authors: Thomas Wallach, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny, Drew Adler, Yuanyuan Zhai, Victor Kumbol, Omar Dzaye, Jutta Schüler, Matthias Futschik…

A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study

A detailed understanding of the pathological processes involved in genetic frontotemporal dementia is critical in order to provide the patients with an optimal future treatment. Protein levels in CSF have the ...

Authors: Sofia Bergström, Linn Öijerstedt, Julia Remnestål, Jennie Olofsson, Abbe Ullgren, Harro Seelaar, John C. van Swieten, Matthis Synofzik, Raquel Sanchez-Valle, Fermin Moreno, Elizabeth Finger, Mario Masellis, Carmela Tartaglia, Rik Vandenberghe, Robert Laforce, Daniela Galimberti…

CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice

Neurocognitive impairment is present in 50% of HIV-infected individuals and is often associated with Alzheimer’s Disease (AD)-like brain pathologies, including increased amyloid-beta (Aβ) and Tau hyperphosphor...

Authors: Biju Bhargavan, Shawna M. Woollard, Jo Ellyn McMillan and Georgette D. Kanmogne

Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans

Parkinson’s disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by α-synuclein oligomers. There is an urgent need for disease-modifying therapies for Pa...

Authors: Kevin S. Chen, Krystal Menezes, Jarlath B. Rodgers, Darren M. O’Hara, Nhat Tran, Kazuko Fujisawa, Seiya Ishikura, Shahin Khodaei, Hien Chau, Anna Cranston, Minesh Kapadia, Grishma Pawar, Susan Ping, Aldis Krizus, Alix Lacoste, Scott Spangler…

The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives

Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as alternatives to classical monotarget therapies and microRNAs are of particular interest in that regard. MicroRNA resear...

Authors: Hannah Walgrave, Lujia Zhou, Bart De Strooper and Evgenia Salta

Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain

Mitochondrial dysfunction is a feature of neurodegenerative diseases, including Alzheimer’s disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and increased mitochondrial DNA mutation burden ...

Authors: Hans-Ulrich Klein, Caroline Trumpff, Hyun-Sik Yang, Annie J. Lee, Martin Picard, David A. Bennett and Philip L. De Jager

Talking points for physicians, patients and caregivers considering Aduhelm® infusion and the accelerated pathway for its approval by the FDA

Authors: Sam Gandy, David S. Knopman and Mary Sano

Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors

Aldh1a1 neurons are a subtype of gamma-aminobutyric acid (GABA) inhibitory neurons that use Aldh1a1 rather than glutamate decarboxylase (GAD) as an enzyme for synthesizing GABA transmitters. However, the behav...

Authors: Xinyan Li, Wenting Chen, Xian Huang, Wei Jing, Tongmei Zhang, Quntao Yu, Hongyan Yu, Hao Li, Qing Tian, Yumei Ding and Youming Lu

Correction to: Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery

Authors: Bing Bai, David Vanderwall, Yuxin Li, Xusheng Wang, Suresh Poudel, Hong Wang, Kaushik Kumar Dey, Ping-Chung Chen, Ka Yang and Junmin Peng

Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy

Oxidative stress (OS) is an imbalance between oxidant and antioxidant species and, together with other numerous pathological mechanisms, leads to the degeneration and death of motor neurons (MNs) in amyotrophi...

Authors: Silvia Bono, Marco Feligioni and Massimo Corbo

METTL3-dependent RNA m⁶A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events

N6-methyladenosine (m⁶A) modification of RNA influences fundamental aspects of RNA metabolism and m⁶A dysregulation is implicated in various human diseases. In this study, we explored the potential role of RNA m⁶

Authors: Fanpeng Zhao, Ying Xu, Shichao Gao, Lixia Qin, Quillan Austria, Sandra L. Siedlak, Kinga Pajdzik, Qing Dai, Chuan He, Wenzhang Wang, James M. O’Donnell, Beisha Tang and Xiongwei Zhu

The TGFβ/Notch axis facilitates Müller cell-to-epithelial transition to ultimately form a chronic glial scar

Contrasting with zebrafish, retinal regeneration from Müller cells (MCs) is largely limited in mammals, where they undergo reactive gliosis that consist of a hypertrophic response and ultimately results in vis...

Authors: Federica Maria Conedera, Ana Maria Quintela Pousa, Nadia Mercader, Markus Tschopp and Volker Enzmann

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques

Increasing evidence for a direct contribution of astrocytes to neuroinflammatory and neurodegenerative processes causing Alzheimer’s disease comes from molecular and functional studies in rodent models. Howeve...

Authors: Pranav Preman, Julia TCW, Sara Calafate, An Snellinx, Maria Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison M Goate, Bart De Strooper and Amaia M Arranz

Measuring the cognitive costs of the COVID-19 pandemic

Authors: Gregory S Day

Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing

Aberrant alternative splicing plays critical role in aging and age-related diseases. Heterogeneous nuclear ribonucleoproteins (hnRNPs) reportedly regulate RNA splicing process. Whether and how hnRNPs contribut...

Authors: Qingyang Zhang, Juan Zhang, Jin Ye, Xiaohui Li, Hongda Liu, Xiaolin Ma, Chao Wang, Keqiang He, Wei Zhang, Ji Yuan, Yingjun Zhao, Huaxi Xu and Qiang Liu

Nuclear dynamics and stress responses in Alzheimer’s disease

In response to extracellular and intracellular stressors, the nucleus and nuclear compartments undergo distinct molecular changes to maintain cell homeostasis. In the context of Alzheimer’s disease, misfolded ...

Authors: Artemis Iatrou, Eric M. Clark and Yanling Wang

Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment

Human genetic association studies point to immune response and lipid metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer’s disease (AD) etiology. Accumulating evidence suggests...

Authors: Shulan Qiu, Juan Pablo Palavicini, Jianing Wang, Nancy S. Gonzalez, Sijia He, Elizabeth Dustin, Cheng Zou, Lin Ding, Anindita Bhattacharjee, Candice E. Van Skike, Veronica Galvan, Jeffrey L. Dupree and Xianlin Han

Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model

The misfolding of host-encoded proteins into pathological prion conformations is a defining characteristic of many neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and Lewy body...

Authors: Grace M. Lloyd, Jess-Karan S. Dhillon, Kimberly-Marie M. Gorion, Cara Riffe, Susan E. Fromholt, Yuxing Xia, Benoit I. Giasson and David R. Borchelt

APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis

Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer’s disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of Apolipoprotein E (APOE), the strongest...

Authors: Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney, Margaret A. Piron, Grant K. Nation, David J. Carter, Adeline E. Walsh, Rebika Khanal, Lyndsay E. A. Young, Jude C. Kluemper, Gabriela Hernandez, Elizabeth J. Allenger, Rachel Mooney, Lesley R. Golden, Cathryn T. Smith, J. Anthony Brandon…

Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation

Mutations in FUS, an RNA-binding protein involved in multiple steps of RNA metabolism, are associated with the most severe forms of amyotrophic lateral sclerosis (ALS). Accumulation of cytoplasmic FUS is likel...

Authors: Inmaculada Sanjuan-Ruiz, Noé Govea-Perez, Melissa McAlonis-Downes, Stéphane Dieterle, Salim Megat, Sylvie Dirrig-Grosch, Gina Picchiarelli, Diana Piol, Qiang Zhu, Brian Myers, Chao-Zong Lee, Don W Cleveland, Clotilde Lagier-Tourenne, Sandrine Da Cruz and Luc Dupuis

Functional microRNA targetome undergoes degeneration-induced shift in the retina

MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-related macular degeneration (AMD), acting as post-transcriptional gene suppressors through thei...

Authors: Joshua A. Chu-Tan, Adrian V. Cioanca, Zhi-Ping Feng, Yvette Wooff, Ulrike Schumann, Riemke Aggio-Bruce, Hardip Patel, Matt Rutar, Katherine Hannan, Konstantin Panov, Jan Provis and Riccardo Natoli

Extracellular protein components of amyloid plaques and their roles in Alzheimer’s disease pathology

Alzheimer’s disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ) peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary tangles. Extensive rese...

Authors: M. Mahafuzur Rahman and Christofer Lendel

Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains

In the post-GWAS era, there is an unmet need to decode the underpinning genetic etiologies of late-onset Alzheimer’s disease (LOAD) and translate the associations to causation.

Authors: Julio Barrera, Lingyun Song, Julia E. Gamache, Melanie E. Garrett, Alexias Safi, Young Yun, Ivana Premasinghe, Daniel Sprague, Danielle Chipman, Jeffrey Li, Hélène Fradin, Karen Soldano, Raluca Gordân, Allison E. Ashley-Koch, Gregory E. Crawford and Ornit Chiba-Falek

Cellular and pathological heterogeneity of primary tauopathies

Microtubule-associated protein tau is abnormally aggregated in neuronal and glial cells in a range of neurodegenerative diseases that are collectively referred to as tauopathies. Multiple studies have suggeste...

Authors: Dah-eun Chloe Chung, Shanu Roemer, Leonard Petrucelli and Dennis W. Dickson

Vesicle trafficking and pathways to neurodegeneration

Authors: Craig Blackstone, Fiona Elwood, Helene Plun-Favreau and Patrick A. Lewis

Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery

Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzheimer’s disease (AD). Here we review the advances and limitations in historic an...

Authors: Bing Bai, David Vanderwall, Yuxin Li, Xusheng Wang, Suresh Poudel, Hong Wang, Kaushik Kumar Dey, Ping-Chung Chen, Ka Yang and Junmin Peng

Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures

Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. Thus, understanding of ...

Authors: Melanie Barth, Mehtap Bacioglu, Niklas Schwarz, Renata Novotny, Janine Brandes, Marc Welzer, Sonia Mazzitelli, Lisa M. Häsler, Manuel Schweighauser, Thomas V. Wuttke, Deborah Kronenberg-Versteeg, Karina Fog, Malene Ambjørn, Ania Alik, Ronald Melki, Philipp J. Kahle…

SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identific...

Authors: Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo…

Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem motor neuron disease for which currently there is no effective treatment. There is an urgent need to identify biomarkers to tackle the disea...

Authors: Laura Pasetto, Stefano Callegaro, Alessandro Corbelli, Fabio Fiordaliso, Deborah Ferrara, Laura Brunelli, Giovanna Sestito, Roberta Pastorelli, Elisa Bianchi, Marina Cretich, Marcella Chiari, Cristina Potrich, Cristina Moglia, Massimo Corbo, Gianni Sorarù, Christian Lunetta…

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration

Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an intracellular and secreted pro-protein that is prot...

Authors: Swetha Mohan, Paul J. Sampognaro, Andrea R. Argouarch, Jason C. Maynard, Mackenzie Welch, Anand Patwardhan, Emma C. Courtney, Jiasheng Zhang, Amanda Mason, Kathy H. Li, Eric J. Huang, William W. Seeley, Bruce L. Miller, Alma Burlingame, Mathew P. Jacobson and Aimee W. Kao

Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease

Disease-associated microglia (DAMs), that surround beta-amyloid plaques, represent a transcriptionally-distinct microglial profile in Alzheimer’s disease (AD). Activation of DAMs is dependent on triggering rec...

Authors: Christel Claes, Emma Pascal Danhash, Jonathan Hasselmann, Jean Paul Chadarevian, Sepideh Kiani Shabestari, Whitney E. England, Tau En Lim, Jorge Luis Silva Hidalgo, Robert C. Spitale, Hayk Davtyan and Mathew Blurton-Jones

The informed road map to prevention of Alzheimer Disease: A call to arms

Alzheimer disease (AD) prevention trials hold the promise to delay or prevent cognitive decline and dementia onset by intervening before significant neuronal damage occurs. In recent years, the first AD preven...

Authors: Eric McDade, Jorge J. Llibre-Guerra, David M. Holtzman, John C. Morris and Randall J. Bateman

Post-infection cognitive impairments in a cohort of elderly patients with COVID-19

Understanding the long-term effects of coronavirus disease 2019 (COVID-19) on cognitive function is essential for monitoring the cognitive decline in the elderly population. This study aims to assess the curre...

Authors: Yu-Hui Liu, Ye-Ran Wang, Qing-Hua Wang, Yang Chen, Xian Chen, Ying Li, Yuan Cen, Cheng Xu, Tian Hu, Xu-Dong Liu, Ling-Li Yang, Si-Jing Li, Xue-Fei Liu, Chun-Mei Liu, Jie Zhu, Wei Li…

Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia

Microglia are active modulators of Alzheimer’s disease but their role in relation to amyloid plaques and synaptic changes due to rising amyloid beta is unclear. We add novel findings concerning these relations...

Authors: Diana P. Benitez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Natalie Wong, Katie M. Stringer, Karina S. Vitanova, Victoria C. Smith, Dhaval Joshi, Takashi Saito, Takaomi C. Saido, John Hardy, Jörg Hanrieder, Bart De Strooper…

Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains

Neuritic plaques in Alzheimer’s disease (AD) brains refer to β-amyloid (Aβ) plaques surrounded by dystrophic neurites (DNs), activated microglia and reactive astrocytes. Most recently, we showed that DNs form ...

Authors: Md Golam Sharoar, Sarah Palko, Yingying Ge, Takaomi C. Saido and Riqiang Yan

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Novel targets to arrest neurodegeneration in several dementing conditions involving misfolded protein accumulations may be found in the diverse signaling pathways of the Mammalian/mechanistic target of rapamyc...

Authors: Henry Querfurth and Han-Kyu Lee