Molecular Neurodegeneration

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Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease

Authors: Artem Zatcepin, Johannes Gnörich, Boris-Stephan Rauchmann, Laura M. Bartos, Stephan Wagner, Nicolai Franzmeier, Maura Malpetti, Xianyuan Xiang, Yuan Shi, Samira Parhizkar, Maximilian Grosch, Karin Wind-Mark, Sebastian T. Kunte, Leonie Beyer, Carolin Meyer, Desirée Brösamle…

Content type: Research article 5 September 2024
Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease

Authors: Qiang Chen, Luis Aguirre, Guoming Liang, Huanhuan Zhao, Tao Dong, Felix Borrego, Itziar de Rojas, Qichan Hu, Christopher Reyes, Ling-Yan Su, Bao Zhang, James D. Lechleiter, Harald H. H. Göring, Philip L. De Jager, Joel E. Kleinman, Thomas M. Hyde…

Content type: Research article 29 August 2024
Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency

Authors: Panpan Wang, Yaping Shao, Murad Al-Nusaif, Jun Zhang, Huijia Yang, Yuting Yang, Kunhyok Kim, Song Li, Cong Liu, Huaibin Cai and Weidong Le

Content type: Research article 26 August 2024
Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy

Authors: Hui Wang, Timothy S. Chang, Beth A. Dombroski, Po-Liang Cheng, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C. Van Swieten, Elise Dopper…

Content type: Research article 16 August 2024
Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease

Authors: Anantharaman Shantaraman, Eric B. Dammer, Obiadada Ugochukwu, Duc M. Duong, Luming Yin, E. Kathleen Carter, Marla Gearing, Alice Chen-Plotkin, Edward B. Lee, John Q. Trojanowski, David A. Bennett, James J. Lah, Allan I. Levey, Nicholas T. Seyfried and Lenora Higginbotham

Content type: Research article 6 August 2024

FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms

TREM2 dependent and independent functions of microglia in Alzheimer’s disease

APOE effects on regional tau in preclinical Alzheimer’s disease

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer’s disease: review, recommendation, implementation and application

Tauopathies: new perspectives and challenges

Advances in sequencing technologies for amyotrophic lateral sclerosis research

ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies

Solving neurodegeneration: common mechanisms and strategies for new treatments

Aims and scope

Molecular Neurodegeneration (MN) is an open access, peer-reviewed journal dedicated to publishing groundbreaking research in the field of neurodegeneration. Our mission is to foster a deeper understanding of neurodegenerative diseases, including but not limited to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, glaucoma, and macular degeneration, to inform novel diagnosis and effective therapy. We aim to publish innovative studies addressing the complex mechanisms of neurodegenerative disorders at the molecular, cellular, and systems levels, with a strong emphasis on broad impact and scientific rigor.

Collections

Glial and Vascular Contributions to Neurodegenerative Diseases

See Molecular Neurodegeneration's ongoing Collection on Glial and Vascular Contributions to Neurodegenerative Diseases.

ALS: Challenges and New Advances

New Content Item

See Molecular Neurodegeneration's ongoing Collection on ALS: Challenges and New Advances.

Ongoing and Past Collections

Glial and Vascular Contributions to Neurodegenerative Diseases
ALS: Challenges and New Advances
Alzheimer's Disease: Challenges for the next decade
Parkinson's Disease - A Series of Reviews
Novel Systems and Emerging Concepts
Basic biology and disease pathways

News from Alzforum

Nix Tryptophan Metabolite, Temper Alzheimer’s?

06 September 2024
CSF Proteomics Hints at How ApoE4 Promotes AD, and How a Drug Hinders It

06 September 2024
Among Icelanders, Blood Proteome Predicts Dementia, Parses Role of ApoE4

06 September 2024

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Molecular Neurodegeneration

Articles

Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease

Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease

Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency

Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy

Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease

Aims and scope

Collections

Glial and Vascular Contributions to Neurodegenerative Diseases

ALS: Challenges and New Advances

Ongoing and Past Collections

Glial and Vascular Contributions to Neurodegenerative Diseases
ALS: Challenges and New Advances
Alzheimer's Disease: Challenges for the next decade
Parkinson's Disease - A Series of Reviews
Novel Systems and Emerging Concepts
Basic biology and disease pathways

News from Alzforum

Nix Tryptophan Metabolite, Temper Alzheimer’s?

CSF Proteomics Hints at How ApoE4 Promotes AD, and How a Drug Hinders It

Among Icelanders, Blood Proteome Predicts Dementia, Parses Role of ApoE4

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