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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Altered hippocampus synaptic function in selenoprotein P deficient mice

Figure 2

Sepp1 (-/-) mice show reduced motor coordination and normal anxiety. (A) Average latency to fall off the rotorod from 4 trials for 2 consecutive days (n = 16 mice per genotype). Statistical analysis of Day 1 Sepp1(-/-):Sepp1(+/+) *p < 0.0001, Day 2 Sepp1(-/-):Sepp1(+/+) *p = 0.0008, Day 1 Sepp1(-/-):Day 2 Sepp1(-/-) #p = 0.006, Day 1 Sepp1(+/+):Day 2 Sepp1(+/+) #p = 0.01. (B) Total distance traveled during 15 min in the open field (n = 16 mice per genotype, p = 0.26). (C) Zone analysis of the time spent in the center of the open field during 15 min. (D) Time spent resting in each of the arm conditions of the elevated plus maze (n = 16 mice per genotype).

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