Figure 3
From: The generation and function of soluble apoE receptors in the CNS
Soluble apoE receptors. Processing by γ-secretase cleaves ApoER2, VLDLR, and LRP1 at the membrane. Cleavage by furin can release soluble forms of ApoER2 and LRP. In addition, sheddase cleavage can result in soluble forms of all four receptors. Soluble ApoER2 fragments from furin or sheddase cleavage contain the ligand-binding regions necessary for interaction with Reelin and apoE. These soluble fragments can block endogenous ligand binding to full length receptor acting in a dominant negative fashion.