Model of APP processing pathways mediated by LDL receptor family members. LRP endocytosis enhances APP endocytosis and processing to Aβ. Due to its slow rate of endocytosis LRP1B retains APP at the cell surface and decreases its processing to Aβ. ApoER2 enhances interactions between APP and F-spondin at the cell surface and also decreases its processing to Aβ. SorLA/LR11 may shuttle APP to the Golgi and prevent its processing by β-secretase in the early endosome, thus decreasing processing to Aβ.