Figure 4
From: Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice
No increased oxidative damage in the brains of DJ-1 -/- mice. (A and B) Similar staining of DNA and RNA oxidative damage in the SN of DJ-1-/- mice and wild-type controls at the age of 24–27 months showing no abnormal accumulation of DNA and RNA oxidative damage in aged DJ-1-/- mice. (C and D) Similar 4HNE staining in the SN of DJ-1-/- mice and wild-type controls showing no abnormal accumulation of lipid peroxidation products in aged DJ-1-/- mice. (E and F) Similar nitrotyrosine staining in the SN of DJ-1-/- mice and wild-type controls showing no abnormal accumulation of oxidative protein damage in aged DJ-1-/- mice. Scale bars; A-F, 0.1 mm.