Tau phosphorylation by GSK-3β promotes tangle-like filament morphology

Table 1 Tau sites phosphorylated by GSK-3β.

sites	Reynolds^a	Connell^b	Rankin^c
T175	+		*
T181	+		*
S199	+	+	+
T205			+
T212	+	+	+
S214			+
T217	+	+	+
T231	+	+	+
S235	+	+	*
S262			+
S356			+
S396	+	+	+
S400	+	+	+
S404	+	+	+
S409			+
S422

Identification of in vitro phosphorylated sites by mass spectrometry
^a Reynolds, et al. study [37]
^b Connell, et al. study [38]
^c Identification of in vitro phosphorylated sites by phosphorylation site-specific antibodies. Antibodies were unavailable for those sites marked with an asterisk. S422, not identified by either mass spectrometry or antibody analysis, was a negative control.

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