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Figure 3 | Molecular Neurodegeneration

Figure 3

From: ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

Figure 3

ApoER2 and APP interact independently of the cytosolic domain of ApoER2. Cell extracts were prepared from ApoER2- and ApoER2 Tailess-expressing N2a cells transiently transfected with APP695-Myc. Extracts were immunoprecipitated with anti-Myc and probed for ApoER2 and for APP with the anti-HA and anti-Myc antibodies, respectively. Remnants of ApoER2 detection after stripping and reblot are indicated by an asterisk.

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Molecular Neurodegeneration

ISSN: 1750-1326