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Figure 7 | Molecular Neurodegeneration

Figure 7

From: Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment

Figure 7

T0 decreases the expression of pro-inflammatory genes in APP23 mice. 7 month old APP23 mice (n = 5) were treated by gastric gavage with T0 at a dose of 50 mg/kg/day for 24 hours (A) or 4 weeks (B), 6 times a week and age-matched control mice (n = 5) received vehicle. At the end of the treatment total RNA was isolated from cortices and hippocampi and mRNA expression of indicated genes determined by RT-QPCR. Values are means ± SEM and represent fold of change compared to vehicle treatment (two-tailed Student's t test).

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