Table 1 Differential expression of genes in brains of APP23 mice treated with T0 or vehicle. Fold change is expressed as ratio of vehicle versus T0 induced expression level, at p < 0.05.
Fold change | Gene symbol | Gene product/cluster |
|---|---|---|
Up-regulated | ||
Lipid metabolism and transport | ||
4.60 | Fabp1 | fatty acid binding protein 1, liver |
3.40 | Acaa1b | acetyl-Coenzyme A acyltransferase 1B |
2.70 | Gc | group specific component (transport of vitamin D sterols) |
2.27 | Apoa2 | apolipoprotein A-II |
2.27 | Apoc1 | apolipoprotein C-I |
1.75 | Abca1 | ATP-binding cassette, sub-family A (ABC1), member 1 (3 copies) |
1.60 | Hmgcs2 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 |
1.59 | Apod | apolipoprotein D |
1.56 | Cpt1a | carnitine palmitoyltransferase 1a, liver |
1.49 | Apoc3 | apolipoprotein C-III |
1.37 | Scd1 | stearoyl-Coenzyme A desaturase 1 |
Metabolism of xenobiotics and detoxification | ||
5.45 | Cyp3a11 | cytochrome P450, family 3, subfamily a, polypeptide 11 |
2.07 | Cyp4a10 | cytochrome P450, family 4, subfamily a, polypeptide 10 |
1.90 | Cyp2e1 | cytochrome P450, family 2, subfamily e, polypeptide 1 |
1.85 | Cyp2c29 | cytochrome P450, family 2, subfamily c, polypeptide 29 |
1.74 | Ugt1a2 | UDP glucuronosyltransferase 1 family, polypeptide A2 (3 copies) |
1.57 | Adh1 | alcohol dehydrogenase 1 (class I) |
Down-regulated | ||
Immune response and response to stress and inflammation | ||
3.60 | Igk-V28 | immunoglobulin kappa chain variable 28 (V28) |
2.33 | Serpina3n | serine (or cysteine) peptidase inhibitor, clade A, member 3N |
1.93 | Ngp | neutrophilic granule protein |
1.90 | Gp49a | glycoprotein 49 A /// leukocyte immunoglobulin-like receptor |
1.68 | Ifitm1 | interferon induced transmembrane protein 1 |
1.63 | Tirap | toll-interleukin 1 receptor (TIR) domain-containing adaptor protein |
1.62 | Gbp2 | guanylate nucleotide binding protein 2 |
1.58 | Fcgr2b | Fc receptor, IgG, low affinity IIb |
1.52 | Cd74 | CD74 antigen (invariant polypeptide of MCH, class II antigen-associated) |
1.50 | Tnfaip6 | |
1.49 | H2-Aa | tumor necrosis factor alpha induced protein 6 |
1.49 | Aif1 | histocompatibility 2, class II antigen A, alpha |
1.46 | Gbp4 | allograft inflammatory factor 1 |
1.40 | H2-D1 | guanylate nucleotide binding protein 4 |
1.40 | Hif3a /// | histocompatibility 2, D region locus 1 |
LOC64109 | hypoxia inducible factor 3, alpha subunit /// similar to hypoxia inducible factor 3, alpha subunit | |
Cell death and apoptosis | ||
2.15 | Wwox | WW domain-containing oxidoreductase |
1.65 | Card10 | caspase recruitment domain family, member 10 |
1.58 | Hccs | holocytochrome c synthetase |
1.55 | Elmo1 | engulfment and cell motility 1, ced-12 homolog (C. elegans) |
1.39 | Fadd | Fas (TNFRSF6)-associated via death domain |
1.50 | Hccs | holocytochrome c synthetase |
1.39 | Sphk1 | sphingosine kinase 1 |