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Table 1 Differential expression of genes in brains of APP23 mice treated with T0 or vehicle. Fold change is expressed as ratio of vehicle versus T0 induced expression level, at p < 0.05.

From: Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment

Fold change Gene symbol Gene product/cluster
   Up-regulated
   Lipid metabolism and transport
4.60 Fabp1 fatty acid binding protein 1, liver
3.40 Acaa1b acetyl-Coenzyme A acyltransferase 1B
2.70 Gc group specific component (transport of vitamin D sterols)
2.27 Apoa2 apolipoprotein A-II
2.27 Apoc1 apolipoprotein C-I
1.75 Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 (3 copies)
1.60 Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
1.59 Apod apolipoprotein D
1.56 Cpt1a carnitine palmitoyltransferase 1a, liver
1.49 Apoc3 apolipoprotein C-III
1.37 Scd1 stearoyl-Coenzyme A desaturase 1
   Metabolism of xenobiotics and detoxification
5.45 Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11
2.07 Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10
1.90 Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1
1.85 Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29
1.74 Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 (3 copies)
1.57 Adh1 alcohol dehydrogenase 1 (class I)
   Down-regulated
   Immune response and response to stress and inflammation
3.60 Igk-V28 immunoglobulin kappa chain variable 28 (V28)
2.33 Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N
1.93 Ngp neutrophilic granule protein
1.90 Gp49a glycoprotein 49 A /// leukocyte immunoglobulin-like receptor
1.68 Ifitm1 interferon induced transmembrane protein 1
1.63 Tirap toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
1.62 Gbp2 guanylate nucleotide binding protein 2
1.58 Fcgr2b Fc receptor, IgG, low affinity IIb
1.52 Cd74 CD74 antigen (invariant polypeptide of MCH, class II antigen-associated)
1.50 Tnfaip6  
1.49 H2-Aa tumor necrosis factor alpha induced protein 6
1.49 Aif1 histocompatibility 2, class II antigen A, alpha
1.46 Gbp4 allograft inflammatory factor 1
1.40 H2-D1 guanylate nucleotide binding protein 4
1.40 Hif3a /// histocompatibility 2, D region locus 1
  LOC64109 hypoxia inducible factor 3, alpha subunit /// similar to hypoxia inducible factor 3, alpha subunit
   Cell death and apoptosis
2.15 Wwox WW domain-containing oxidoreductase
1.65 Card10 caspase recruitment domain family, member 10
1.58 Hccs holocytochrome c synthetase
1.55 Elmo1 engulfment and cell motility 1, ced-12 homolog (C. elegans)
1.39 Fadd Fas (TNFRSF6)-associated via death domain
1.50 Hccs holocytochrome c synthetase
1.39 Sphk1 sphingosine kinase 1