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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Lack of α-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease

Figure 4

Western blotting of 18-month-old of APP and APP/Snca-/- animals. A. 10 μg of forebrain lysates were separated on SDS-PAGE, transferred to a nitrocellulose membrane and probed with antibodies against α-synuclein, APP, synaptophysin and α-tubulin. No difference in APP or β-synuclein expression could be detected. α-synuclein was absent from APP/Snca-/- animals, and synaptophysin levels were increase in APP/Snca-/- animals. B. Quantification of band intensity of synaptophysin from APP vs APP/Snca-/- animals. Data was normalized to tubulin bands (**p < 0.01).

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Molecular Neurodegeneration

ISSN: 1750-1326