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Table 1 Ginkgolide B does not affect PGE2-induced loss of synaptophysin.

From: Ginkgolides protect against amyloid-β1–42-mediated synapse damage in vitro

  Synaptophysin content (units)
  Pre-treatment
  None Ginkgolide B (1 μM) AH13205 (100 nM)
None 100 ± 5 101 ± 3 102 ± 3
1–42 (200 nM) 24 ± 4 93 ± 7 97 ± 6
PAF (10 nM) 33 ± 7 78 ± 5 89 ± 8
PGE 2 (40 nM) 41 ± 6 44 ± 7 96 ± 4
Butaprost (1 μM) 29 ± 5 37 ± 11 94 ± 7
Misprostal (1 μM) 32 ± 7 34 ± 6 98 ± 5
  1. The effects of pre-treatment with ginkgolide B, or with the EP receptor antagonist AH13205 on the synaptophysin content of neuronal cultures incubated for 24 hours with Aβ1–42, PAF, PGE2, or with the EP receptors agonists butaprost or misoprostol as shown. Values shown are the mean synaptophysin content ± SD from 9 observations.