Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice

Table 1 Differentially expressed gene groups between the PSKO and CNT mice regardless of age or brain region.

#	NAME	SIZE	ES	NES	p-val	q-val
1	GABAPATHWAY	11	0.68	1.59	*0.046748*	0.147418
2	AGPCRPATHWAY	10	0.67	1.45	*0.019068*	0.243600
3	RAC1PATHWAY	21	-0.59	-1.30	*0.020121*	0.418927
4	D4GDIPATHWAY	10	-0.68	-1.31	*0.043478*	0.397110
5	ALKPATHWAY	32	-0.55	-1.34	*0.014085*	0.298667
6	NTHIPATHWAY	19	-0.61	-1.35	*0.040936*	0.290866
7	TGFBPATHWAY	13	-0.67	-1.42	*0.010142*	0.163844
8	MCALPAINPATHWAY	22	-0.53	-1.44	*0.005848*	0.179323
9	INTRINSICPATHWAY	20	-0.58	-1.45	*0.020534*	0.177983
10	LAIRPATHWAY	10	-0.67	-1.45	*0.046185*	0.198237
11	VITCBPATHWAY	10	-0.51	-1.45	*0.038776*	0.228195
12	TOB1PATHWAY	14	-0.73	-1.63	*0.004082*	0.087297
13	EXTRINSICPATHWAY	12	-0.71	-1.69	*0.014614*	0.082402
14	NKCELLSPATHWAY	15	-0.50	-1.70	*0.025490*	0.138997

The whole dataset was subjected to pathway analysis with BioCarta using GSEA. Significantly enriched pathways are presented in either direction (positive NES – enriched in CNT; negative NES – enriched in PSKO). Abbreviations: SIZE- number of non-redundant probes in a pathway; ES – enrichment score; NES – normalized enrichment score; p-val – groupwise p value; q-val – groupwise false discovery ratio estimate. Note that only 2 pathways were enriched in the CNT mice (GABA and AGPCR), while the PSKO mice samples were enriched in 12 pathways.

ISSN: 1750-1326