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Table 1 Differentially expressed gene groups between the PSKO and CNT mice regardless of age or brain region.

From: Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice

# NAME SIZE ES NES p-val q-val
1 GABAPATHWAY 11 0.68 1.59 0.046748 0.147418
2 AGPCRPATHWAY 10 0.67 1.45 0.019068 0.243600
3 RAC1PATHWAY 21 -0.59 -1.30 0.020121 0.418927
4 D4GDIPATHWAY 10 -0.68 -1.31 0.043478 0.397110
5 ALKPATHWAY 32 -0.55 -1.34 0.014085 0.298667
6 NTHIPATHWAY 19 -0.61 -1.35 0.040936 0.290866
7 TGFBPATHWAY 13 -0.67 -1.42 0.010142 0.163844
8 MCALPAINPATHWAY 22 -0.53 -1.44 0.005848 0.179323
9 INTRINSICPATHWAY 20 -0.58 -1.45 0.020534 0.177983
10 LAIRPATHWAY 10 -0.67 -1.45 0.046185 0.198237
11 VITCBPATHWAY 10 -0.51 -1.45 0.038776 0.228195
12 TOB1PATHWAY 14 -0.73 -1.63 0.004082 0.087297
13 EXTRINSICPATHWAY 12 -0.71 -1.69 0.014614 0.082402
14 NKCELLSPATHWAY 15 -0.50 -1.70 0.025490 0.138997
  1. The whole dataset was subjected to pathway analysis with BioCarta using GSEA. Significantly enriched pathways are presented in either direction (positive NES – enriched in CNT; negative NES – enriched in PSKO). Abbreviations: SIZE- number of non-redundant probes in a pathway; ES – enrichment score; NES – normalized enrichment score; p-val – groupwise p value; q-val – groupwise false discovery ratio estimate. Note that only 2 pathways were enriched in the CNT mice (GABA and AGPCR), while the PSKO mice samples were enriched in 12 pathways.