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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease

Figure 4

Bdnf promoter-specific expression analyses in R6/2 cortex. Relative expression ratios to the geometric mean of three housekeeping genes for Bdnf promoter-specific transcripts in R6/2 (filled bars) and littermate wild-type controls (open bars). Data from 4, 8, 12 and 15 weeks (4 w, 8 w, 12 w and 15 w) represents the pathogenic time course from pre-symptomatic stages through to late symptomatic stages for Bdnf promoter-specific transcripts (A) I, (B) IIa, (C) IIb, (D) IIc, (E) III, (F) IV, (G) V and (H) coding exon VIII, according to Liu et al., 2006 [39]. Error bars are S.E.M (n = 8), * p < 0.05, ** p < 0.01, *** p < 0.001.

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Molecular Neurodegeneration

ISSN: 1750-1326