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Figure 8 | Molecular Neurodegeneration

Figure 8

From: Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

Figure 8

CLUSTER heatmap showing distributions of expression ratios for named genes from differentiated, rotenone-treated SH-SY5Y neural cells. Total RNA samples from the three independent rotenone incubation experiments were hybridized in duplicate on 19.2K glass microarrays. Following analysis for significance with B.A.G.E.L. software, the transcripts with P < 0.05 significance were annotated with DAVID to named genes and processed with CLUSTER to generate the heatmap. Shown are the distributions of the 1200 genes that were present in at least 50% of the samples across the time (days) of rotenone exposure. Gray spaces indicate that a particular transcript was not present. The colorbar above the heatmap shows the natural logarithm of the averaged rotenone/CTL values.

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Molecular Neurodegeneration

ISSN: 1750-1326