Table 2 Examination of Aβ values from conditioned media of HEK-293 derived stable cell lines expressing both Swedish APP and each of PS1 genes.
Cell Line | Transfected PS1 Constructs | Aβ1–40 (pg/ml) | Aβ1–42 (pg/ml) | Ratio of Aβ42/Aβ |
|---|---|---|---|---|
H125.3-16 | ---- | 3152 ± 47 (n = 6) | 337 ± 36 (n = 6) | 0.097 ± 0.010 |
" | PS1 | 8379 ± 170 (n = 3) | 1123 ± 20 (n = 6) | 0.118 ± 0.002 |
" | PS1-M146V | 9507 ± 129 (n = 3) | 2627 ± 52 (n = 3) | 0.217 ± 0.004** |
" | PS1-D257TG | 9716 ± 192 (n = 3) | 1099 ± 35 (n = 6) | 0.102 ± 0.003* |
" | PS1-D385TG | 7783 ± 225 (n = 3) | 16647 ± 799 (n = 3) | 0.681 ± 0.033** |
" | PS1-D257TG/D385TG | 5390 ± 218 (n = 3) | 6941 ± 97 (n = 3) | 0.563 ± 0.008** |