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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells

Figure 1

27-OHC, but not 24-OHC, increases levels of secreted Aβ42. While treatment with 5, 10 and 25 μM 24-OHC did not alter Aβ42 levels (a), treatment with 5, 10 and 25 μM 27-OHC significantly increased levels of Aβ42 compared to levels in medium of untreated cells (b). There was no difference in Aβ42 levels between untreated cells and cells treated with a mixture of 24-OHC + 27-OHC (c). **p < 0.01 (One way ANOVA followed by Dunnett's multiple comparison test).

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Molecular Neurodegeneration

ISSN: 1750-1326