LY-411575 treatment reduced Aβ40 and 42 plasma levels in APPswe/PS1dE9xYFP mice. Animals received daily oral administration of LY-411575 (5 mg/Kg) or vehicle for 3 weeks. Plasma samples were taken before starting the treatment (session 1) and on a weekly basis for the next 3 weeks. All measurements were done in duplicate and data are representative of 3–5 mice. We observed a significant sessionXtreatment effect [F(2,14) = 6.307; P = 0.011] and [F(2,14) = 11.806; P = 0.001] for Aβ40 and 42 respectively. Student-t test for independent sessions showed significant differences for both measurements after the first week of treatment when compared with control values. Differences were maintained until the end of the treatment (*p < 0.05).