Effect of acute apoE exposure on NR2A and NR2B tyrosine phosphorylation. ApoE-deficient slices treated with 100 nM rhapoE isoforms. A) Ratio of pNR2A as measured by pTyr immunoreactivity to NR2A immunoreactivity as immunoprecipatated by NR2A. B) Ratio of pNR2B as measured by pTyr immunoreactivity to NR2B immunoreactivity as immunoprecipatated by NR2B. control (C, light grey), rhapoE2 (E2, medium grey), rhapoE3 (E3, dark grey), rhapoE4 (E4, black). Data expressed as mean ± SEM.