Chronic apoE isoform expression alters activation of ERK1/2 and JNK1/2. A) Quantification of levels of pERK (i) or ERK (ii) immunoreactivity in CA1 of apoE TR, wild-type, and apoE deficient animals. iii) pERK/ERK ratio. B) Quantification of levels of pJNK (i) or JNK (ii) immunoreactivity in CA1 of apoE TR, wild-type, or apoE deficient animals. iii) pJNK/JNK ratio. Quantification of immunoreactivity normalized to background (n = 5). C57BL/6J (WT, white), apoE-deficient (E0, light grey), apoE2 TR (E2, medium grey), apoE3 TR (E3, dark grey), apoE4 TR (E4, black). Data expressed as mean ± SEM. *p < 0.05, ANOVA with Bonferroni's posttest.