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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Nucleation of protein aggregation kinetics as a basis for genotype-phenotype correlations in polyglutamine diseases

Figure 2

Linear regression analysis of HD and DRPLA based on the model. (A) A total of 317 HD patients with expanded CAG repeats in the huntingtin gene was analyzed. Inspection of logarithmically transformed mean age-at-onset versus CAG size plots identified 75 and 121 CAG as relative outliers. These data were therefore excluded from further study. A regression analysis of natural log-transformed (tA2 - tE2)1/2 against CAG size provided the best fit to a linear model (-0.0662x + 6.657) when tE2 = 215. (B) A total of 91 DRPLA patients with expanded CAG repeats in the atrophin-1 gene was analyzed. Inspection of logarithmically transformed mean age-at-onset versus CAG size plots identified 69 and 79 CAG repeats as relative outliers. These data were excluded from further study. A regression analysis of natural log-transformed (tA2 - tE2)1/2 against CAG size provided the best fit to a linear model (-0.1247x + 11.011) when tE2 = 0.

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Molecular Neurodegeneration

ISSN: 1750-1326