Figure 2

I ¹²⁵ – Aβ fragments following APEH cleavage. Soluble Aβ peptide iodinated on amino acid 10 was incubated for 5 hours with or without purified APEH. Following incubation, samples were separated on a 10–20% Tris-tricine gel. The gel was then dried and exposed to film. Full length uncut Aβ fragment, as well as the cleaved Aβ fragments containing the radiolabeled Lys¹⁰ are seen on the autoradiograph. Above the autoradiograph is the amino acid sequence of the Aβ peptide. * denotes iodinated amino acid. Arrows indicate APEH cleavage sites.