Ultrastructural analysis of microvascular pathology in LDLR-/- and C57BL/6J mice. Additional examples of microvascular pathology from LDLR-HCD (A, B, E, F), LDLR-LCD (C), and C57BL-HCD (D) are shown. In A and B, note the severely degenerating microvessels in an LDLR mouse fed a high cholesterol diet. In C, note the thickened basal laminae (white asterisk), expanded perivascular space (black asterisk), and degenerating capillary wall (arrowhead) in an LDLR-/- mouse fed a LCD. In D, an arrow indicates an expanded perivascular space filled with amorphous debris in a C57BL/6J mouse fed a HCD. Examples of degeneration in the capillary wall in LDLR-HCD mice are indicated by arrowheads in panels E and F. Scale bar in B = 2 μm for panels A and B; scale bar in D = 500 nm for panels C-F.