Figure 5
From: Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain
Quantitation of FL-SORL1 as a function of synaptophysin expression and Braak stage. Individuals that have Braak stages that are low (0-II, open circles), moderate (Braak III-V, green circles) or high (VI, black-filled circles) are indicated. Linear regression analyses found that both synaptophysin and Braak stage (two degrees of freedom) were significantly associated with SORL1 expression, (p < 0.001 and p = 0.015, respectively). Synaptophysin expression showed only a slight trend towards decreased expression with Braak stage, which did not achieve significance (p = 0.55, ANOVA)