Disease | Lesions | Major Protein In Deposit | Genetic Alterations |
---|---|---|---|
Alzheimer's | Plaques NFT | Aβ tau | Mutations/Multiplication in APP and Presenilin genes cause altered Aβ production |
Parkinson's (classic)1 | Lewy Body | α-synuclein | Mutation/Multiplication of α-synuclein gene |
FTDP-17tau | NFT | tau | Mutations in tau |
FTLDu | Ubiquitin positive inclusions | TDP-43 | Mutations in Granulin gene, evidence that Granulin interacts with TDP-43 |
Polyglutamine Diseases (e.g. Huntington's, SCA) | Inclusions of expanded Poly Q protein | PolyQ encoding protein | Expanded CAG repeats encoded stretches of Poly Q |
ALS | Ubiquitin positive inclusions | TDP-43 | Mutations in TDP-43 |
ALS | Ubiquitin positive inclusions | Inclusions are TDP negative | Mutations in SOD1 |