Figure 1

Rotarod performance of WT and YAC128 mice. An average latency to fall from the accelerating rotarod is shown for the WT control (Ctrl) mice (open blue circles), the YAC128 (YAC) control mice (filled blue circles), the WT mice fed with Early-TBZ (open red squares), the YAC128 mice fed with Early-TBZ (filled red squares), the WT mice fed with Late-TBZ (open black triangles), and the YAC128 mice fed with Late-TBZ (filled black triangles). For each group of mice, the results are shown as mean ± SEM at 2, 6, 9, 11 and 13 month (washout) time points. At 6, 9, 11 and 13 months of age, control WT mice performed significantly better (p < 0.05) than control YAC128 mice. Early-TBZ feeding to WT mice had no apparent effects on their rotarod performance at 6 months, but caused significant (p < 0.05) reduction at 9 and 11 months when compared to control WT group. Similar to the Early-TBZ group, Late-TBZ feeding to WT mice had no apparent effects at 9 months, but caused significant (p < 0.05) reduction at 11 months compared to control WT group. Early-TBZ feeding to YAC mice significantly improved (p < 0.05) their rotarod performance at 6, 9, 11 and 13 months when compared to control YAC128 mice. Late-TBZ feeding (6 months of age) to YAC mice significantly improved (p < 0.05) the rotarod performance at 9, 11 and 13 months compared to control YAC128 mice. However, both YAC-TBZ feeding groups performed significantly worse (p < 0.05) than any of WT groups.