The Aβ isoform pattern separates SAD from controls and depressed patients. The figure shows OPLS-DA on the two classes SAD and non-AD (controls and depression) using the data shown in figure 2. (A) Score plot for SAD (open circles), depression (solid squares) and controls (solid triangles). (B) Loading and (C) variable importance on projection (VIP) plots for the Aβ fragments. The error bars in (C) represent a 95% confidence interval.