Figure 2

Aβ oligomers but not Aβ fibrils reduce the amplitude of fEPSP without affect the PPF. (A, left), Superimposed, average (10 sweeps) of fEPSPs before (a) and after 40 min of Aβ oligomers perfusion (b). (A, right), Superimposed, normalized (to R1), averaged (10 sweeps) fEPSPs evoked by paired pulse stimulation (100 ms delay) in control and in presence of Aβ oligomers (a+b), and time course of Aβ oligomer effects on fEPSPs. a) baseline, b) effect of Aβ oligomers and c) washout with ACSF. (B) Summary data of fEPSPs amplitude (left) and facilitation index in control and after Aβ oligomers treatment. (n = 5). (C) Superimposed, average (10 sweeps) of EPSCs evoked by single and paired pulse protocol, before (control, gray trace) and after 40 min of continued perfusion with Aβ oligomers (black trace). (D) Summary date of EPSCs amplitude (right) and facilitation index (left) in control and after Aβ oligomers treatment, respectively. (n = 5). (E) Superimposed, normalized (to R1), averaged (10 sweeps) fEPSPs evoked by paired pulse stimulation in control and in presence of Aβ fibrils. (F), Summary date of fEPSPs amplitude (left) and facilitation index (right) in control and after Aβ fibrils treatment (n = 4). Bar represents the mean ± SEM (*p < 0.05 Student's t test).