Normalized RXRα (Black bars) and LXRβ mRNA (white bars) expression in hippocampus plotted against CDR scores, Braak neuropathological stages and NP density groups. ANCOVA was used to compare gene expression in individuals with varying degree of dementia (CDR 0.5-5) and AD-associated neuropathology (Braak stage I-VI, NP density 2-5) relative to the control group. Mean values ± SEM are shown. *, p < 0.05; **, p < 0.01. Number within the parentheses indicates the individuals within control groups and each of the disease severity group.