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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease

Figure 2

Reduced activation of HIF-1α downstream target genes in Psen1-/- fibroblasts treated with cobalt chloride. Psen1+/+ (wt) or Psen1-/- fibroblasts were treated with cobalt chloride for the indicated times (hours). Levels of Vegf (A) and Glut-1 (B) RNA were determined by qPCR (n = 9 cultures per group untreated; n = 3 per group treated). (*) indicates p < 0.05 and (**) p < 0.01 vs. untreated control by Dunnett's post-test. Statistical comparisons between groups are discussed further in the text.

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Molecular Neurodegeneration

ISSN: 1750-1326