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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease

Figure 4

Effect of α-SYN over-expression on microglial activation in wild-type and FcγR-/- mice. A-D) At four weeks after AAV injection, SN sections of wild-type and FcγR-/- mice over-expressing α-SYN or GFP were double-stained for gp91PHOX (red) and SYN/GFP (green). Wild-type mice expressing α-SYN revealed significantly increased immunoreactivity for gp91PHOX compared to the other three groups. gp91PHOX immunoreactivity was localized to microglia, which appear to be close to α-SYN-expressing neurons (scale bar = 50 μm). E) Scoring of microglial activation using a rating scale revealed significant microglial activation in wild-type mice expressing α-SYN compared to those expressing GFP. This difference was not observed in FcγR-/- mice expressing SYN or GFP. *p < 0.05, WT-SYN vs WT-GFP, Mann-Whitney U test.

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Molecular Neurodegeneration

ISSN: 1750-1326