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Figure 5 | Molecular Neurodegeneration

Figure 5

From: PrPScaccumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases

Figure 5

Colocalization of total PrPSc (rPrPSc + sPrPSc) and synaptophysin in synaptosomes. Confocal micrographs of a "crude" synaptosomal preparation obtained from the Sc237 prion strain infected hamsters at 70 dpi show total PrPSc (green) and synaptophysin (red) (mouse monoclonal anti-synaptophysin, clone SY38, DakoCytomation). Merged images show colocalization of total PrPSc and synaptophysin in yellow. Bar represents 20 μm. Adapted from Bouzamondo-Bernstein et al. [5].

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Molecular Neurodegeneration

ISSN: 1750-1326