Model output for less efficient DNA repair. A-E Five simulations over 8 day time period. F Mean (solid lines) and standard deviation (dashed lines) of 100 simulations. An event to mimic irradiation took place 1 hour after the start of the simulation. The parameter for DNA repair was reduced by an order of magnitude (k
= 2.0E-6). All other parameter values used are given in Tables 2 and 3. Levels of p53 (total pool, including bound and ubiquitinated species), Mdm2 (total pool, including bound and ubiquitinated species), p53 bound to GSK3β, damaged DNA (damDNA), ROS levels (scaled by a factor of 5 to be seen more clearly), Aβ plaques and Tau tangles are shown. Key: green line: p53, red line: Mdm2, gray line: GSK3b_p53, purple line: damaged DNA, blue line: Tau tangles, cyan line: Abeta plaques, black line: ROS levels ×5.