Figure 6
From: GSK3 and p53 - is there a link in Alzheimer's disease?
Model output for increased aggregation rate. A-E Five simulations over 12 day time period. F Mean (solid lines) and standard deviation (dashed lines) of 100 simulations. No irradiation. The parameters for aggregation were increased by two orders of magnitude. (k aggTauP = kaggTauP1 = k aggAbeta = 1.0E-6, kaggTauP2 = 1.0E-5). All other parameter values used are given in Tables 2 and 3. Levels of p53 (total pool, including bound and ubiquitinated species), Mdm2 (total pool, including bound and ubiquitinated species), p53 bound to GSK3β, damaged DNA (damDNA), Aβ plaques and Tau tangles are shown. Key: green line: p53, red line: Mdm2, gray line: GSK3b_p53, purple line: damaged DNA, blue line: Tau tangles, cyan line: Abeta plaques.