Table 1 List of model species
From: GSK3 and p53 - is there a link in Alzheimer's disease?
Name | Description | Database term | Initial amount |
|---|---|---|---|
GSK3b | Unbound GSK3β protein | P49841 | 500 |
GSK3b_p53 | GSK3β bound to p53 | P49841, P04637 | 0 |
GSK3b_p53_P | GSK3β bound to phosphorylated p53 | P49841, P04637 | 0 |
p53 | Unbound p53 protein | P04637 | 5 |
Mdm2 | Unbound Mdm2 protein | Q00987 | 5 |
Mdm2_p53 | Mdm2/p53 complex | Q00987, P04637 | 95 |
Mdm2_mRNA | Mdm2 messenger RNA | SBO:0000278 | 10 |
p53_mRNA | p53 messenger RNA | SBO:0000278 | 10 |
p53_P | Phosphorylated p53 | P04637 | 0 |
Mdm2_P | Phosphorylated Mdm2 | Q00987 | 0 |
Ub | Ubiquitin | P62988 | 4000 |
E1 | Ubiquitin activating enzyme | IPR000011 | 100 |
E2 | Ubiquitin conjugating enzyme | IPR000608 | 100 |
E1_Ub | E1 bound by Ub | IPR000011, P62988 | 0 |
E2_Ub | E2 bound by Ub | IPR000608, P62988 | 0 |
p53DUB | Deubiquitinating enzyme for p53 | IPR001394 | 200 |
Mdm2DUB | Deubiquitinating enzyme for Mdm2 | IPR001394 | 200 |
Mdm2_p53_Ub | Monoubiquitinated p53 | Q00987, P04637, P62988 | 0 |
Mdm2_p53_UbX (X = 2-4) | Polyubiquitinated p53 | Q00987, P04637, P62988 | 0 |
Mdm2_P1_p53_Ub4 | Phosphorylated Mdm2 bound to p53 | Q00987, P04637, P62988 | 0 |
Mdm2_Ub | Monoubiquitinated Mdm2 | Q00987, P62988 | 0 |
Mdm2_P_Ub | Monoubiquitinated phospho-Mdm2 | Q00987, P62988 | 0 |
Mdm2_UbX (X = 2-4) | Polyubiquitinated Mdm2 | Q00987, P62988 | 0 |
Mdm2_P_UbX (X = 2-4) | Polyubiquitinated phospho-Mdm2 | Q00987, P62988 | 0 |
Proteasome | 26S Proteasome complex | GO:0000502 | 500 |
p53_Ub4_Proteasome | p53 bound to proteasome | P04637, P62988, GO:0000502 | 0 |
Mdm2_Ub4_Proteasome | Mdm2 bound to proteasome | Q00987, P62988, GO:0000502 | 0 |
Mdm2_P_Ub4_Proteasome | phospho-Mdm2 bound to proteasome | Q00987, P62988, GO:0000502 | 0 |
ATMI | Inactive ATM | Q13315 | 200 |
ATMA | Active ATM | Q13315 | 0 |
damDNA | Amount of damaged DNA | CHEBI16991 | 0 |
IR | Dummy species to represent gamma-irradiation | - | 0 |
ROS | Reactive oxygen species | CHEBI:26523 | 0 |
basalROS | Basal pool of ROS | CHEBI:26523 | 10 |
Abeta | Amyloid beta | P05067 | 0 |
AggAbeta | Small aggregate of Aβ | P05067 | 0 |
AbetaPlaque | Aβ plaque | P05067 | 0 |
AggAbeta_Proteasome | AggAbeta bound to the proteasome | P05067, GO:0000502 | 0 |
Tau | tau | IPR002955 IPR002955 | 0 |
Proteasome_Tau | tau bound to 20S proteasome | GO:0000502, | 0 |
Tau_P1 | tau phosphorylated by GSK3β at one site | IPR002955 | 0 |
Tau_P2 | tau phosphorylated by GSK3β at two sites | IPR002955 | 0 |
MT_Tau | tau bound to the microtubule | IPR015562 | 100 |
AggTau | small aggregate of tau | IPR002955 | 0 |
AggTau_Proteasome | AggTau bound to proteasome | IPR002955, GO:0000502 | |
NFT | tau neurofibrillary tangle | IPR002955 | 0 |
PP1 | phosphatase | P62136 | 50 |
ATP | Adenosine triphosphate | CHEBI:15422 | 10000 |
ADP | Adenosine diphosphate | CHEBI:16761 | 1000 |
AMP | Adenosine monophosphate | CHEBI:22254 | 1000 |