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Table 6 Analysis of PGC1α Block 2 Haplotypes on HD age-at-onset

From: Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease

Haplotype Frequency Score P value
1-1-1-1-2 0.2072 -1.892 0.0585
1-2-1-1-1 0.1550 -1.636 0.1018
1-1-1-2-1 0.1469 -1.218 0.2232
1-1-1-1-1 0.1269 0.749 0.4538
1-1-2-1-1 0.0725 1.125 0.2606
1-1-1-2-1 0.0665 1.724 0.0847
2-1-1-1-1 0.0511 2.886 0.0039
  1. n = 729; adjusted for CAG repeat size (CAGlog)
  2. P = 0.0113 for global haplotype statistics; block 2 haplotypes: 1, more common allele (+38570T, +74774A, +75657C, +75919G, +76059G); 2, less common allele (+38570C, +74554G, +75657T, +75919A, +76059A)