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Table 6 Analysis of PGC1α Block 2 Haplotypes on HD age-at-onset

From: Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease

Haplotype

Frequency

Score

P value

1-1-1-1-2

0.2072

-1.892

0.0585

1-2-1-1-1

0.1550

-1.636

0.1018

1-1-1-2-1

0.1469

-1.218

0.2232

1-1-1-1-1

0.1269

0.749

0.4538

1-1-2-1-1

0.0725

1.125

0.2606

1-1-1-2-1

0.0665

1.724

0.0847

2-1-1-1-1

0.0511

2.886

0.0039

  1. n = 729; adjusted for CAG repeat size (CAGlog)
  2. P = 0.0113 for global haplotype statistics; block 2 haplotypes: 1, more common allele (+38570T, +74774A, +75657C, +75919G, +76059G); 2, less common allele (+38570C, +74554G, +75657T, +75919A, +76059A)
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Molecular Neurodegeneration

ISSN: 1750-1326