Skip to main content
Figure 1 | Molecular Neurodegeneration

Figure 1

From: A mutation in the dynein heavy chain gene compensates for energy deficit of mutant SOD1 mice and increases potentially neuroprotective IGF-1

Figure 1

Dynein mutation increased adipose stores in early symptomatic SOD1(G93A) mice. A- mRNA levels of alpha subunit of the nicotinic acetylcholine receptor (AchRα) in gastrocnemius muscles of wild type (+/+) and dynein mutant mice (Cra/+) bearing SOD1(G93A) transgene (SOD1m, black columns) or not (Wt, empty columns) *P < 0.05 versus Wt. mRNA levels were standardized using 18S ribosomal RNA as a control. N = 9 mice per group. B-C- Relative weight of epididimary (EPI) and retroperitoneal (RP) white adipose tissue fat pad with regard to body weight (B). The panel C shows absolute weight (in mg) of EPI and RP in the same mice than in A. *P < 0.05 versus Wt; #, p < 0.05 as indicated. N = 9 mice per group.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326