Table 5 Interactions of various molecules with VLDLR and ApoER2.
From: Similarities and differences in structure, expression, and functions of VLDLR and ApoER2
VLDLR | Â | Ectodomain Interactor | Â | ApoER2 |
|---|---|---|---|---|
unknown | + | Reelin | + | LBR1 |
LBR | + | Thrombospondin F-spondin | + | LBR |
LBR 5-8 | + | ApoE | + | LBR 1-3, 7 |
| Â | - | selenoprotein | + | unknown |
VLDLR | Â | Transmembrane Interactor | Â | ApoER2 |
Releases intracellular domains | + | γ-secretase | + | Releases intracellular domains |
Releases extracellular domains | + | α-secretase | + | Releases extracellular domains |
VLDLR | Â | Cytoplasmic Interactor | Â | ApoER2 |
PTB domain binds 14-residue peptide around the NPxY | + | Dab1 | + | PTB domain binds 14-residue peptide around the NPxY |
| Â | - | Dab2 | + | PTB domain binds NPxY of ApoER2 |
NPxY followed by leucine | + | Pafah1b2 & Pafah1b3 | - | NPxY followed by arginine |
| Â | - | JIP-1, JIP-2 | + | Exon 19 |
| Â | - | PSD-95 | + | Exon 19 |
NPxY | + | FE65 | + | NPxY |