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Table 5 Interactions of various molecules with VLDLR and ApoER2.

From: Similarities and differences in structure, expression, and functions of VLDLR and ApoER2

VLDLR   Ectodomain Interactor   ApoER2
unknown + Reelin + LBR1
LBR + Thrombospondin F-spondin + LBR
LBR 5-8 + ApoE + LBR 1-3, 7
  - selenoprotein + unknown
VLDLR   Transmembrane Interactor   ApoER2
Releases intracellular domains + γ-secretase + Releases intracellular domains
Releases extracellular domains + α-secretase + Releases extracellular domains
VLDLR   Cytoplasmic Interactor   ApoER2
PTB domain binds 14-residue peptide around the NPxY + Dab1 + PTB domain binds 14-residue peptide around the NPxY
  - Dab2 + PTB domain binds NPxY of ApoER2
NPxY followed by leucine + Pafah1b2 & Pafah1b3 - NPxY followed by arginine
  - JIP-1, JIP-2 + Exon 19
  - PSD-95 + Exon 19
NPxY + FE65 + NPxY