Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease

Table 3 Stage 2 Analysis of Top RA-SNPs Associated with AD

		Uncorrected Logistic Regression				Regression Corrected for Age, Sex and APOE
CHR	SNP	OR	L95	U95	P	OR	L95	U95	P
21	rs2837960	1.011	0.887	1.153	0.865	1.000	0.867	1.154	0.997
18	rs2002842	0.992	0.896	1.099	0.880	0.990	0.886	1.106	0.857
9	rs3761847	0.921	0.832	1.019	0.112	0.905	0.809	1.012	0.080

No RA-associated SNP that exhibited an association with AD in Stage 1 was found to exhibit an association with AD in our Stage 2 population. This remained true when data were analyzed and corrected for covariates including age, sex and APOE genotype of Stage 2 individuals, who on average were significantly older than Stage 1 individuals (p < 0.001, Students t-test).

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