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Table 3 Stage 2 Analysis of Top RA-SNPs Associated with AD

From: Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease

  Uncorrected Logistic Regression Regression Corrected for Age, Sex and APOE
CHR SNP OR L95 U95 P OR L95 U95 P
21 rs2837960 1.011 0.887 1.153 0.865 1.000 0.867 1.154 0.997
18 rs2002842 0.992 0.896 1.099 0.880 0.990 0.886 1.106 0.857
9 rs3761847 0.921 0.832 1.019 0.112 0.905 0.809 1.012 0.080
  1. No RA-associated SNP that exhibited an association with AD in Stage 1 was found to exhibit an association with AD in our Stage 2 population. This remained true when data were analyzed and corrected for covariates including age, sex and APOE genotype of Stage 2 individuals, who on average were significantly older than Stage 1 individuals (p < 0.001, Students t-test).