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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus

Figure 3

Leptin does not regulate IGF-1 levels in the presence of a STAT5 inhibitor. (a) Representative Western blot, (b) densitometric analysis, (c) ELISA immunoassay, and (d) Real time RT-PCR demonstrate that treatment of organotypic slices with the selective STAT5 inhibitor for 72 hours significantly decreases IGF-1 expression levels. Concomitant treatment with leptin fails to reverse the decrease in IGF-1 expression levels induced by the STAT5 inhibitor. **p < 0.01 and ***p < 0.001 versus control.

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Molecular Neurodegeneration

ISSN: 1750-1326