Skip to main content
Figure 9 | Molecular Neurodegeneration

Figure 9

From: Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus

Figure 9

IGF-1 fails to regulate C-EBPα expression levels in presence of the mTORC1 inhibitor rapamycin. Western blot and densitometric analyses show that treatment of organotypic slices with the mTORC1 inhibitor rapamycin for 72 hours significantly decreases expression levels of the transcription factor C-EBPα in the cytosol (a,b) and in the nuclear fractions (c,d). IGF-1 treatment does not affect the reduction in cytosolic and nuclear levels of C-EBPα induced by rapamycin, suggesting that the upregulation of the transcription factor C-EBPα is mediated via mTORC1. **p < 0.01 and ***p < 0.001 versus control.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326