Figure 11

Intraperitoneal administration of DJ-1-binding compound-23 (comp-23) reduces infarct size after focal cerebral ischemia and reperfusion. (A) Representative photographs showing coronal brain sections at +3, +1, -1, -3, -5, and -7 mm anterior-posterior from the bregma with TTC staining at 1 day after MCAO in sham-operated rats (n = 6) and MCAO-ischemic rats intraperitoneally administered sterilized physiological saline in the presence of the vehicle (1% DMSO, n = 8) or comp-23 (0.1, 1 and 10 mg/kg containing 1% DMSO, n = 5 in each group), before 10 min and after 2 h of the reperfusion from 120-min MCAO. Scale bar: 1 mm (Sham in A). (B and C) Quantitative analysis of infarct area (B) and volume (C). Data are means ± SEM. Significance (Student's t-test in B; Bonferroni/Dunn post hoc comparisons after ANOVA in C): ***P < 0.001 versus sham-operated rats. †P < 0.05, †††P < 0.001 versus vehicle-injected rats.