Casp2-/- mice are not protected from pathology. A-B) Fixed forebrain and testes weight in 12-month-old mice. YAC128 mice show forebrain atrophy that is not rescued by the absence of casp2 (summary statistics for two-way ANOVA indicated). Mean="+", horizontal bars = quartiles. N = 9 WT mice, 11 YAC128 mice, 9 casp2-/- mice, 14 Casp2-/-;YAC128 mice. C) Striatal volume, as determined by stereology, is reduced in YAC128 mice and not affected by caspase-2 expression. Mean="+", horizontal bars = quartiles, isolated dots = outliers. Factorial ANOVA F/p-values indicated. N = 19 WT mice, 25 YAC128 mice, 21 casp2-/- mice, 22 Casp2-/-;YAC128 mice.